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Smad7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (2) Endogenous Metabolite (2) MMP (1) p38 MAPK (2) PTEN (1) Reactive Oxygen Species (2) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (6)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (3)

9

Inhibitors & Agonists

2

Natural
Products

5

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Mongersen sodium GED-0301 sodium	TGF-beta/Smad	Inflammation/Immunology
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .

Asiaticoside 10+ Cited Publications	p38 MAPK TGF-beta/Smad Reactive Oxygen Species Apoptosis Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses *TGF-β/Smad* signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

Smad7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smad7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smad7 Rat Pre-designed siRNA Set A Smad7 Rat Pre-designed siRNA Set A

SMAD7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD7 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD7 Human Pre-designed siRNA Set A SMAD7 Human Pre-designed siRNA Set A

Smad7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smad7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smad7 Mouse Pre-designed siRNA Set A Smad7 Mouse Pre-designed siRNA Set A

Mongersen GED-0301	TGF-beta/Smad	Inflammation/Immunology
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .

CIB-L43	PTEN TGF-beta/Smad Akt	Cancer
CIB-L43 is an orally active TRBP inhibitor (K_D = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC₅₀ = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration .

Asiaticoside (Standard)	p38 MAPK TGF-beta/Smad Reactive Oxygen Species Apoptosis Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Asiaticoside (Standard) is the analytical standard of Asiaticoside. This product is intended for research and analytical applications. Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

Stevia Powder	MMP TGF-beta/Smad	Others
Stevia Powder is a natural sweetener with antioxidant activity. Stevia Powder can downregulate pro fibrotic pathways in cirrhotic rats, including reduced hepatic myofibroblasts and decreased expression of matrix metalloproteinases MMP2 and MMP13, upregulate anti fibrotic molecule *Smad7*, prevent serum necrosis and elevated bile stasis markers, thereby inhibiting the development of liver fibrosis .

Cat. No.	Product Name		Classification

Mongersen sodium GED-0301 sodium		Antisense Oligonucleotides
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .

Smad7 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Smad7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SMAD7 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smad7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Smad7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mongersen GED-0301		Antisense Oligonucleotides
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .

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