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Isoforms Recommended: SphK2
Results for "

SphK2

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147282
    Amgen-23

    		SphK Cancer
    Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer .
    Amgen-23
  • HY-15779A
    K145 hydrochloride
    5+ Cited Publications

    		 SphK Apoptosis Cancer
    K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity .
    K145 hydrochloride
  • HY-RS13667
    SPHK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SPHK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPHK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SPHK2 Human Pre-designed siRNA Set A
    SPHK2 Human Pre-designed siRNA Set A
  • HY-RS13668
    Sphk2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sphk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sphk2 Mouse Pre-designed siRNA Set A
    Sphk2 Mouse Pre-designed siRNA Set A
  • HY-RS13669
    Sphk2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sphk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sphk2 Rat Pre-designed siRNA Set A
    Sphk2 Rat Pre-designed siRNA Set A
  • HY-151350
    SphK2-IN-1

    		SphK Cardiovascular Disease Inflammation/Immunology Cancer
    SphK2-IN-1 is a SphK2 inhibitor (IC50: 0.359 μM). SphK2-IN-1 can be used in the research of cancer, inflammation, neurological and cardiovascular disorders .
    SphK2-IN-1
  • HY-151351
    SphK2-IN-2

    		SphK Cancer
    SphK2-IN-2 (21g) is a potent and selective SphK2 inhibitor with an IC50 value of 0.23 μM .
    SphK2-IN-2
  • HY-162580
    SphK2-IN-3

    		SphK Cancer
    SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2 .
    SphK2-IN-3
  • HY-15779
    K145

    		SphK Apoptosis Cancer
    K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity .
    K145
  • HY-W019781
    Biotinylated sphingosine

    Biotinyl-Sph

    		 SphK Metabolic Disease
    Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 .
    Biotinylated sphingosine
  • HY-148707
    SphK1&2-IN-1

    		SphK Cardiovascular Disease Inflammation/Immunology Cancer
    SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability [2].
    SphK1&2-IN-1
  • HY-120268A
    SLM6031434 hydrochloride

    		SphK Inflammation/Immunology Cancer
    SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research [2].
    SLM6031434 hydrochloride
  • HY-19794
    MP-A08

    		SphK Cancer
    MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
    MP-A08
  • HY-150513
    SLP9101555

    		SphK Cancer
    SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (Ki=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels .
    SLP9101555
  • HY-150615
    SphK1-IN-2

    		SphK Apoptosis Cancer
    SphK1-IN-2 is a potent, selective SphK1 inhibitor with IC50 values of 19.81 nM and ＞10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research .
    SphK1-IN-2
  • HY-15425
    PF-543
    Maximum Cited Publications
    8 Publications Verification

    Sphingosine Kinase 1 Inhibitor II

    		 SphK LPL Receptor Apoptosis Autophagy Cardiovascular Disease Inflammation/Immunology Cancer
    PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy [2] .
    PF-543
  • HY-15425B
    PF-543 hydrochloride

    Sphingosine Kinase 1 Inhibitor II hydrochloride

    		 SphK LPL Receptor Apoptosis Autophagy Cardiovascular Disease Inflammation/Immunology Cancer
    PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy [2] .
    PF-543 hydrochloride
  • HY-15425A
    PF-543 Citrate
    Maximum Cited Publications
    8 Publications Verification

    Sphingosine Kinase 1 Inhibitor II Citrate

    		 SphK LPL Receptor Apoptosis Autophagy Cardiovascular Disease Inflammation/Immunology Cancer
    PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy [2] .
    PF-543 Citrate
  • HY-12892
    SKI-178

    		SphK Apoptosis Cancer
    SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. SKI-178 is cytotoxic at IC50 concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines [2].
    SKI-178

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