SLM6031434 hydrochloride

Name: SLM6031434 hydrochloride
Brand: MedChemExpress
SKU: HY-120268A
Rating: 4.5 (1 reviews)

Cat. No.: HY-120268A Purity: 99.1%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with K_is of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research.

For research use only. We do not sell to patients.

SLM6031434 hydrochloride Chemical Structure

CAS No. : 1897379-34-8

Size	Price	Stock	Quantity
1 mg	USD 159	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 398	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 638	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SLM6031434 hydrochloride:

SLM6031434 Get quote

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SphK1 SphK2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

489.96

Formula

C₂₂H₃₁ClF₃N₅O₂

CAS No.

1897379-34-8

Appearance

Solid

Color

White to off-white

SMILES

N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 40 mg/mL (81.64 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0410 mL	10.2049 mL	20.4098 mL
5 mM	0.4082 mL	2.0410 mL	4.0820 mL
10 mM	0.2041 mL	1.0205 mL	2.0410 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.1%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0410 mL	10.2049 mL	20.4098 mL	51.0246 mL
	5 mM	0.4082 mL	2.0410 mL	4.0820 mL	10.2049 mL
	10 mM	0.2041 mL	1.0205 mL	2.0410 mL	5.1025 mL
	15 mM	0.1361 mL	0.6803 mL	1.3607 mL	3.4016 mL
	20 mM	0.1020 mL	0.5102 mL	1.0205 mL	2.5512 mL
	25 mM	0.0816 mL	0.4082 mL	0.8164 mL	2.0410 mL
	30 mM	0.0680 mL	0.3402 mL	0.6803 mL	1.7008 mL
	40 mM	0.0510 mL	0.2551 mL	0.5102 mL	1.2756 mL
	50 mM	0.0408 mL	0.2041 mL	0.4082 mL	1.0205 mL
	60 mM	0.0340 mL	0.1701 mL	0.3402 mL	0.8504 mL
	80 mM	0.0255 mL	0.1276 mL	0.2551 mL	0.6378 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.