TCP

By Targets:	Apoptosis (2) Endogenous Metabolite (1) Fluorescent Dye (1) Histone Demethylase (6) HSP (1) iGluR (1) Monoamine Oxidase (3) P2X Receptor (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (4) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136522

S2116	Histone Demethylase Apoptosis	Cancer
S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice .

HY-136523

S2157	Histone Demethylase Apoptosis	Cancer
S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells .

HY-103000

HSF1A 1 Publications Verification	HSP	Cardiovascular Disease Cancer
HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1) . HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding .

HY-D1420

TCP-BP-SFAC	Fluorescent Dye	Others
TCP-BP-SFAC is a luminogenic molecule. TCP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films, with photoluminescence (PL) peaks at ~483 nm and delayed fluorescence lifetimes of 5.4 to 5.7 μs .

HY-108668

TC-P 262	P2X Receptor	Others
TC-P 262 is a potent P2X3 inhibitor. TC-P 262 shows inhibition by bindings to hP2X3. TC-P 262 has the potential for the research of rheumatoid arthritis, cough, and pain .

HY-161848

TCP-MP-CA	Histone Demethylase	Cancer
TCP-MP-CA (compound 11a) is an inhibitor of LSD1 demethylation enzymatic via binding to LSD1/CoREST complex. TCP-MP-CA exhibits an inhibitory effect on osteoclastogenesis, with an IC₅₀ value of 0.14 µM .

HY-RS14321

TCP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TCP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TCP1 Human Pre-designed siRNA Set A TCP1 Human Pre-designed siRNA Set A

HY-RS14322

TCP11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TCP11 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TCP11 Human Pre-designed siRNA Set A TCP11 Human Pre-designed siRNA Set A

HY-RS14324

TCP11L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TCP11L2 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TCP11L2 Human Pre-designed siRNA Set A TCP11L2 Human Pre-designed siRNA Set A

HY-RS14323

TCP11L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TCP11L1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TCP11L1 Human Pre-designed siRNA Set A TCP11L1 Human Pre-designed siRNA Set A

HY-P3319

β-Neuroprotectin	iGluR	Neurological Disease
β-Neuroprotectin is a (3H)TCP binding inhibitor with activity against NMDA-mediated neuronal cell death. β-Neuroprotectin can effectively inhibit the binding of [3H]TCP. β-Neuroprotectin provides neuroprotection at low concentrations against NMDA-induced neuronal cell death .

HY-148542

EpoY SD-142	Endogenous Metabolite	Cardiovascular Disease Cancer
EpoY (SD-142) acts as an irreversible inhibitor of the brain's primary tubulin tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and the small vasohibin binding protein (SVBP). By inhibiting TCP with an IC₅₀ value of approximately 500 nM, EpoY effectively decreases levels of detyrosinated alpha-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition leads to significant differentiation defects and has been linked to underlying issues associated with cancer and cardiomyopathies.

HY-144758

LSD1-IN-17	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 17.2 μM .

HY-144756

LSD1-IN-15	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM .

HY-144757

LSD1-IN-16	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 15.2 μM .

Cat. No.	Product Name	Target	Research Area

HY-P3319

β-Neuroprotectin	iGluR	Neurological Disease
β-Neuroprotectin is a (3H)TCP binding inhibitor with activity against NMDA-mediated neuronal cell death. β-Neuroprotectin can effectively inhibit the binding of [3H]TCP. β-Neuroprotectin provides neuroprotection at low concentrations against NMDA-induced neuronal cell death .

Species:	Human (4) Mouse (1)
Tag:	His (3) SUMO (2) Tag Free (1) Avi (1) Fc (1)
Source:	HEK293 (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72120

	CCT2 Protein, Human (His-SUMO) 99D8.1; CCT 2; CCT beta; CCT-beta; CCT2; CCTB; Chaperonin containing t complex polypeptide 1 beta subunit; Chaperonin containing TCP1 subunit 2 beta; ; HEL S 100n; MGC142074; MGC142076; MGC94480; PRO1633; T complex protein 1 beta subunit; T complex protein 1 subunit beta; T-complex protein 1 subunit beta; TCP 1 beta; TCP-1-beta; TCPB_HUMAN	Human	E. coli
	The CCT2 protein is an important component of the chaperone-containing T complex (TRiC), a molecular chaperone that assists in protein folding through ATP hydrolysis. CCT2 Protein, Human (His-SUMO) is the recombinant human-derived CCT2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P78249

	RANTES/CCL5 Protein, Mouse (HEK293, Fc) MuRantes; SIS-delta; Scya5; Ccl5; D17S136E; eoCP; RANTES; SCYA5; SISd; TCP228; CCL5	Mouse	HEK293
	RANTES/CCL5 Protein, Mouse (HEK293, Fc) is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis.RANTES/CCL5 Protein, Mouse (HEK293, Fc) is a recombinant mouse RANTES/CCL5 (S24-S91) protein expressed by HEK293 with a hFc tag at the N-terminu.

HY-P700861

	RANTES/CCL5 Protein, Human (Biotinylated, His-Avi) MuRantes; SIS-delta; Scya5; Ccl5; D17S136E; eoCP; RANTES; SCYA5; SISd; TCP228; CCL5	Human	E. coli
	RANTES/CCL5 protein attracts monocytes, memory T-helper cells, and eosinophils, releases histamine, and activates eosinophils. It interacts with chemokine receptors CCR1, CCR3, CCR4, and CCR5. It inhibits HIV and may promote neuron survival and insulin secretion via GPR75. RANTES/CCL5 Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived RANTES/CCL5 protein, expressed by E. coli , with N-Avi, N-His labeled tag. The total length of RANTES/CCL5 Protein, Human (Biotinylated, His-Avi) is 68 a.a., with molecular weight of 10.89 kDa.

HY-P70450

	RANTES/CCL5 Protein, Human 3 Publications Verification C-C Motif Chemokine 5; EoCP; Eosinophil Chemotactic Cytokine; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; TCP228; T-Cell-Specific Protein RANTES; CCL5; D17S136E; SCYA5	Human	E. coli
	RANTES/CCL5 Protein is a secreted protein located outside the cell membrane and is a key pro-inflammatory chemokine and immune regulatory molecule in the CC chemokine family. RANTES/CCL5 Protein sends signals through its specific G protein-coupled receptors (GPCR) CCR1, CCR3, and CCR5, mediating inflammatory immune responses, viral infections, and tumor development. RANTES/CCL5 Protein can promote endothelial cell migration, proliferation, and angiogenesis in rats. RANTES/CCL5 Protein is useful for research into tumors, autoimmune diseases, and atherosclerosis. RANTES/CCL5 Protein, Human is a recombinant human CCL5 (S24-S91) protein expressed by E. coli.

HY-P78399

	RANTES/CCL5 Protein, Human (His-SUMO) MuRantes; SIS-delta; Scya5; Ccl5; D17S136E; eoCP; RANTES; SCYA5; SISd; TCP228; CCL5	Human	E. coli
	RANTES/CCL5 Protein, Human (His-SUMO) is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Human (His-SUMO) is a recombinant human RANTES/CCL5 (S24-S91) protein expressed by E. coli with a His and a SUMO tag at the N-terminu.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81459

	SPINK1 Antibody (YA1204) PCTT; PSTI; SPINK1; Spink3; TaTI; TCP; P12	IHC-P	Human
	SPINK1 Antibody (YA1204) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1204), targeting SPINK1. SPINK1 Antibody (YA1204) can be used for IHC-P experiment in human background.

HY-P82638

	RANTES Antibody (YA2383) SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta	WB, ICC/IF	Human
	RANTES Antibody (YA2383) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2383), targeting RANTES, with a predicted molecular weight of 10 kDa (observed band size: 10 kDa). RANTES Antibody (YA2383) can be used for WB, ICC/IF experiment in human background.

HY-P82493

	TCP 1 alpha Antibody (YA2238) TCP1; CCT1; CCTA; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha	WB, IHC-P, ICC/IF, IP	Human
	TCP 1 alpha Antibody (YA2238) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2238), targeting TCP 1 alpha, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). TCP 1 alpha Antibody (YA2238) can be used for WB, IHC-P, ICC/IF, IP experiment in human background.

HY-P82575

	CCT2 Antibody (YA2320) CCT2; 99D8.1; CCTB; T-complex protein 1 subunit beta; TCP-1-beta; CCT-beta	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	CCT2 Antibody (YA2320) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2320), targeting CCT2, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). CCT2 Antibody (YA2320) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P82159

	ILF3 Antibody (YA1904) ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	ILF3 Antibody (YA1904) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1904), targeting ILF3, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). ILF3 Antibody (YA1904) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.

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Cat. No.	Product Name		Classification

HY-RS14321

TCP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TCP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14322

TCP11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TCP11 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14324

TCP11L2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TCP11L2 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14323

TCP11L1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TCP11L1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCP11L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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