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Isoforms Recommended: TET2
Results for "

TET2

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111558
    Bobcat339
    Maximum Cited Publications
    18 Publications Verification

    		 DNA Methyltransferase TET Protein Cancer
    Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .
    Bobcat339
  • HY-402410
    TETi76

    		TET Protein Cancer
    TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research .
    TETi76
  • HY-129079A
    TFMB-(S)-2-HG
    1 Publications Verification

    		 DNA Methyltransferase Wnt β-catenin Endocrinology Cancer
    TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) [2].
    TFMB-(S)-2-HG
  • HY-111558A
    Bobcat339 hydrochloride
    Maximum Cited Publications
    18 Publications Verification

    		 DNA Methyltransferase TET Protein Cancer
    Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .
    Bobcat339 hydrochloride
  • HY-120395
    UC-514321

    		STAT Apoptosis TET Protein Inflammation/Immunology Cancer
    UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .
    UC-514321
  • HY-W018324
    5-Hydroxymethylcytosine

    5hmC

    		 Endogenous Metabolite Metabolic Disease Cancer
    5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development .
    5-Hydroxymethylcytosine
  • HY-RS14385
    TET2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TET2 Human Pre-designed siRNA Set A contains three designed siRNAs for TET2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TET2 Human Pre-designed siRNA Set A
    TET2 Human Pre-designed siRNA Set A
  • HY-RS16656
    Tet2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA)
    Tet2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Tet2 Mouse Pre-designed siRNA Set A
    Tet2 Mouse Pre-designed siRNA Set A

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