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Results for "

TLR antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Toll-like Receptor (TLR) (27) AIM2 (2) Apoptosis (1) Bacterial (1) EBV (2) HIV (1) NF-κB (1) Stearoyl-CoA Desaturase (SCD) (2)
By Research Areas:	Cancer (2) Infection (6) Inflammation/Immunology (24) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	CpG ODNs (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Targets Recommended: Toll-like Receptor (TLR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144619

TLR7/8 antagonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of *TLR7/8* with IC₅₀s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases .

HY-112050

CU-CPT-8m 2 Publications Verification TLR8-specific antagonist	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT-8m is a specific *TLR8* antagonist, with an IC₅₀ of 67 nM.

HY-150751C

ODN TTAGGG sodium ODN A151 sodium	AIM2 Toll-like Receptor (TLR)	Inflammation/Immunology
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-116213

Sparstolonin B 3 Publications Verification	Toll-like Receptor (TLR) HIV	Infection Inflammation/Immunology Cancer
Sparstolonin B acts as a selective *TLR2* and *TLR4* antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities .

HY-131952

TLR7/8/9-IN-1 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC₅₀ = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9).

HY-116961

TH1020 Maximum Cited Publications 6 Publications Verification	Toll-like Receptor (TLR) Bacterial	Infection Inflammation/Immunology
TH1020 is a potent and selective *toll-like receptor 5 (TLR5)/flagellin complex* antagonist with an IC₅₀ of 0.85 μM. TH1020 inhbits flagellin-induced *TLR5* signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8 .

HY-112667

CU-CPT-9a 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT-9a is a specific *TLR8* antagonist, with an IC₅₀ of 0.5 nM.

HY-145886

TLR7/8 antagonist 1	Toll-like Receptor (TLR)	Infection Inflammation/Immunology Cancer
TLR7/8 Antagonist 1 (Compound 16c) is the potent antagonist of *TLR7/8* with IC₅₀s of 3.91 and 2.19 μM, respectively. TLR7/8 Antagonist 1 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders .

HY-153460

TLR7/8/9 antagonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8/9 antagonist 2 is an orally active *TLR7/8/9* antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC₅₀ values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis .

HY-150751

ODN TTAGGG ODN A151	Toll-like Receptor (TLR) AIM2	Inflammation/Immunology
ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-139567

Afimetoran BMS-986256	Toll-like Receptor (TLR) NF-κB Apoptosis	Inflammation/Immunology
Afimetoran (BMS-986256) is an orally active, selective, and highly bioavailable *TLR7/8* antagonist. Afimetoran (BMS-986256) can inhibit *TLR7/8* activation of the NF-κB pathway and reverse *TLR7* mediated resistance to steroid induced apoptosis in plasma cell like dendritic cells (pDCs). Afimetoran (BMS-986256) can be used for research on inflammation and autoimmune diseases (systemic lupus erythematosus) .

HY-125171

IAXO-102 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
IAXO-102 is a *TLR4* antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .

HY-112051

CU-CPT9b 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT9b is a specific *TLR8* antagonist, with an IC₅₀ of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a K_d of 21 nM .

HY-135042

CAY10614 1 Publications Verification	Toll-like Receptor (TLR)	Neurological Disease
CAY10614 is a potent *TLR4* antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC₅₀ of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model .

HY-112146

MMG-11 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 is a potent and selective human *TLR2* antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-112146A

MMG-11 quarterhydrate 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MMG-11 quarterhydrate is a potent and selective human *TLR2* antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses .

HY-131945

CU-115 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-115 is a potent TLR8 antagonist (IC₅₀=1.04 µM), and shows selective for TLR8 over TLR7 (IC₅₀=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells .

HY-P10208

RKH	Toll-like Receptor (TLR)	Infection
PKH is a *TLR4* antagonist. PKH is a novel tripeptide and can be isolated from Akkermansia muciniphila. RKH reduces sepsis-induced inflammatory cell activation and proinflammatory factor overproduction .

HY-120538

CPG-52364	Toll-like Receptor (TLR)	Inflammation/Immunology
CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC₅₀ value of 4.6 nM .

HY-150751A

Biotin-labeled ODN TTAGGG sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150751B

FITC-labeled ODN TTAGGG sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-12756A

E6446 dihydrochloride 1 Publications Verification	Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Inflammation/Immunology
E6446 dihydrochloride is a potent and orally acitve *TLR7* and *TLR9* antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .

HY-12756

E6446 1 Publications Verification	Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Inflammation/Immunology
E6446 is a potent and orally acitve *TLR7* and *TLR9* antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .

HY-105070

Eritoran E5564 free base	EBV Toll-like Receptor (TLR)	Infection
Eritoran （E5564 free base） is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Eritoran has anti-inflammatory activity .

HY-105070A

Eritoran tetrasodium E5564	EBV Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Eritoran tetrasodium (E5564) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity .

HY-118984

CRX-526	Toll-like Receptor (TLR)	Inflammation/Immunology
CRX-526 is a *TLR4* antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model) .

HY-123789

T5342126	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

Cat. No.	Product Name	Target	Research Area

HY-P10208

RKH	Toll-like Receptor (TLR)	Infection
PKH is a *TLR4* antagonist. PKH is a novel tripeptide and can be isolated from Akkermansia muciniphila. RKH reduces sepsis-induced inflammatory cell activation and proinflammatory factor overproduction .

Cat. No.	Product Name		Classification

HY-150751

ODN TTAGGG ODN A151		CpG ODNs
ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-150751A

Biotin-labeled ODN TTAGGG sodium		CpG ODNs
Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150751B

FITC-labeled ODN TTAGGG sodium		CpG ODNs
FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a *TLR9, AIM2* and cGAS antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

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