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TWEAK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Influenza Virus (1) MicroRNA (1) P2X Receptor (1) TNF Receptor (3) Topoisomerase (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)

4

Inhibitors & Agonists

2

Inhibitory Antibodies

11

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

Aurintricarboxylic acid 2 Publications Verification	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the *TWEAK-Fn14* signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM .

TWEAK-Fn14-IN-1	TNF Receptor	Others
TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent *TWEAK-Fn14* inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a K_D of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects .

RG-7212 (RO5458640) RO5458640	TNF Receptor	Inflammation/Immunology
RG-7212 (RO5458640) is a human-derived antibody expressed in CHO cells, targeting *TNFSF12/TWEAK*. RG-7212 (RO5458640) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.02 kDa. The isotype control for RG-7212 (RO5458640) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Target	Research Area

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

RG-7212 (RO5458640) RO5458640	TNF Receptor	Inflammation/Immunology
RG-7212 (RO5458640) is a human-derived antibody expressed in CHO cells, targeting *TNFSF12/TWEAK*. RG-7212 (RO5458640) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.02 kDa. The isotype control for RG-7212 (RO5458640) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (4) Mouse (5) Rat (1) Cynomolgus (1)
Tag:	His (2) Tag Free (1) Fc (8)
Source:	HEK293 (8) CHO (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	TWEAK/TNFSF12 Protein, Mouse (HEK293, Fc) Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Mouse	HEK293
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Mouse TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (25-45 a.a.). TWEAK/TNFSF12 Protein, Mouse (HEK293, Fc) is the extracellular part (R105-H249) of TWEAK protein, produced by HEK293 cells (R105-H249) with N-terminal hFc-tag.

	TWEAK/TNFSF12 Protein, Mouse (HEK293, rFc) Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Mouse	HEK293
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Mouse TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (25-45 a.a.). TWEAK/TNFSF12 Protein, Mouse (HEK293, rFc) is the extracellular part (R105-H249) of TWEAK protein, produced by HEK293 cells (R105-H249) with N-terminal rFc-tag.

	TWEAK/TNFSF12 Protein, Rat (HEK293, Fc) Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Rat	HEK293
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain. TWEAK/TNFSF12 Protein, Rat (HEK293, Fc) is produced by HEK293 cells (R105-H249) with N-terminal rFc-tag.

	TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc) Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Cynomolgus	HEK293
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc) is the extracellular part (S97-H249) of TWEAK protein, produced by HEK293 cells with N-terminal mFc-tag.

	TWEAK/TNFSF12 Protein, Human (CHO) 1 Publications Verification rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L	Human	CHO
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). TWEAK/TNFSF12 Protein, Human (CHO) is the extracellular part (R99-H249) of TWEAK protein, produced by CHO cells with tag free.

	TWEAK/TNFSF12 Protein, Human (HEK293, hFc) APO3 ligand; APO3L; DR3LG; UNQ181/PRO207; TWEAK; MGC129581	Human	HEK293
	TWEAK/TNFSF12 Protein binds to FN14 and potentially TNRFSF12/APO3, weakly inducing apoptosis in certain cells. It activates NF-kappa-B, enhances angiogenesis, and stimulates endothelial cell proliferation. Furthermore, TWEAK/TNFSF12 is implicated in inflammatory cytokine induction and promotes IL8 secretion. It forms a homotrimer and interacts with the angiogenic factor AGGF1/VG5Q. TWEAK/TNFSF12 Protein, Human (HEK293, hFc) is the recombinant human-derived TWEAK/TNFSF12 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TWEAK/TNFSF12 Protein, Human (HEK293, hFc) is 207 a.a., with molecular weight of 50-60 kDa.

	TWEAK/TNFSF12 Protein, Mouse (204a.a, HEK293, rFc) Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Mouse	HEK293
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Mouse TWEAK protein is a type II transmembrane protein with a transmembrane domain. TWEAK/TNFSF12 Protein, Mouse (HEK293, rFc) is the extracellular part of TWEAK protein, produced by HEK293 cells with N-terminal rFc-tag.

HY-P700156AF

	*Animal-Free TWEAK/TNFSF12 Protein, Human (His)* Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG	Human	E. coli
	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). Animal-Free TWEAK/TNFSF12 Protein, Human (His) is the extracellular part (K97-H249) of TWEAK protein, produced by E. coli with C-terminal His-tag.This product is for cell culture use only.

	TNFRSF12A Protein, Human (HEK293, Fc) TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and TWEAK-receptor	Human	HEK293
	TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human (HEK293, Fc) is the recombinant human-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

	TNFRSF12A Protein, Mouse (HEK293, Fc) TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and TWEAK-receptor	Mouse	HEK293
	TNFRSF12A Protein, a receptor for TNFSF12/TWEAK, exhibits a weak apoptosis-inducing ability in specific cells.It promotes angiogenesis and endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins.In functional interactions, TNFRSF12A associates with TRAF1 and TRAF2, possibly with TRAF3, suggesting its involvement in signaling pathways contributing to diverse cellular processes.TNFRSF12A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700229AF

	Animal-Free TNFRSF12A Protein, Mouse (His) TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and TWEAK-receptor	Mouse	E. coli
	TNFRSF12A Protein, a receptor for TNFSF12/TWEAK, exhibits a weak apoptosis-inducing ability in specific cells.It promotes angiogenesis and endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins.In functional interactions, TNFRSF12A associates with TRAF1 and TRAF2, possibly with TRAF3, suggesting its involvement in signaling pathways contributing to diverse cellular processes.Animal-Free TNFRSF12A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTNFRSF12A protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

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	CD266 Antibody (YA2676) CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; TWEAK receptor; TWEAKR	WB, IHC-P, IP	Human, Mouse, Rat
	CD266 Antibody (YA2676) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2676), targeting CD266, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). CD266 Antibody (YA2676) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

	TNFSF12 Antibody (YA1507) TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK	FC, ELISA	Human
	TNFSF12 Antibody (YA1507) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1507), targeting TNFSF12. TNFSF12 Antibody (YA1507) can be used for FC, ELISA experiment in human background.

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