TrxR1

By Targets:	Apoptosis (7) Atg8/LC3 (1) Autophagy (1) Bacterial (2) Farnesyl Transferase (1) Ferroptosis (1) Fluorescent Dye (1) HIV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Keap1-Nrf2 (1) MDM-2/p53 (1) NF-κB (1) Phospholipase (1) Ras (1) Reactive Oxygen Species (1) TNF Receptor (1) TrxR (9)
By Research Areas:	Cancer (13) Infection (4) Inflammation/Immunology (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116749

Ethaselen BBSKE	TrxR	Cancer
Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC₅₀s of 0.5 and 0.35 μM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR .

HY-126322

DVD-445	TrxR	Cancer
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC₅₀ of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application ^[1].

HY-A0068

Aurothioglucose 1 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of *TrxR1* (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities ^[1] .

HY-151978

ZC0109	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Cancer
ZC0109 is a dual inhibitor of *IDO1* and thioredoxin reductase 1 (TrxR1) with IC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis ^[1].

HY-149390

TrxR1-IN-1	TrxR	Cancer
TrxR1-IN-1 (Compound 5j) is a *TrxR1* inhibitor (IC₅₀: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC₅₀s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical ^[1].

HY-120914

TrxR1-IN-B19 GO-Y015	TrxR Apoptosis	Cancer
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent *TrxR1* inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis ^[1].

HY-163724

LW-216	TrxR Apoptosis	Cancer
LW-216 is a *TrxR1* inhibitor that induces Apoptosis. LW-216 has anti-tumor activity ^[1].

HY-168526

Keap1-Nrf2-IN-24	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-24 (compound 57) is a potent *Keap1-Nrf2* inhibitor with a K_i value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability ^[1].

HY-129751

Nitrovin hydrochloride Difurazon hydrochloride	Bacterial TrxR Apoptosis	Infection Cancer
Nitrovin hydrochloride is an antibacterial growth promoter. Nitrovin hydrochloride induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting *TrxR1. Nitrovin hydrochloride has anticancer activity, with IC₅₀* values of 1.31-6.60 μM for tumor and normal cells ^[1].

HY-W504391

Nitrovin Difurazon	Bacterial TrxR Apoptosis	Infection Cancer
Nitrovin is an antibacterial growth promoter. Nitrovin induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting *TrxR1. Nitrovin has anticancer activity, with IC₅₀* values of 1.31-6.60 μM for tumor and normal cells ^[1].

HY-19980

Eprenetapopt 5+ Cited Publications APR-246; PRIMA-1Met	MDM-2/p53 Autophagy Apoptosis Ferroptosis	Cancer
Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance ^[1] .

HY-N6796

Manumycin A	Farnesyl Transferase Ras Apoptosis Phospholipase TNF Receptor Atg8/LC3	Infection Inflammation/Immunology Cancer
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the *Ras/Raf/ERK1/2* signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion ^[1] .

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a *TrxR* inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective ^[1].

HY-D1253

TP-TRFS	TrxR	Neurological Disease
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) .

HY-D1268

Seph-PAO	Fluorescent Dye	Cancer
Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR) .

Cat. No.	Product Name	Type

HY-D1268

Seph-PAO	Fluorescent Dyes/Probes
Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6796

Manumycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Farnesyl Transferase Ras Apoptosis Phospholipase TNF Receptor Atg8/LC3
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the *Ras/Raf/ERK1/2* signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion ^[1] .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P77258

	TRXR1/TXNRD1 Protein, Human (His) Thioredoxin reductase 1, cytoplasmic; GRIM-12; Thioredoxin reductase TR1; TR; KDRF	Human	E. coli
	The homodimeric flavoprotein TRXR1/TXNRD1 plays a key role in cellular redox regulation, growth and differentiation. It reduces the disulfide protein thioredoxin (Trx) to its dithiol-containing form and exhibits reductase activity towards hydrogen peroxide (H2O2). TRXR1/TXNRD1 Protein, Human (His) is the recombinant human-derived TRXR1/TXNRD1 protein, expressed by E. coli , with N-His labeled tag. The total length of TRXR1/TXNRD1 Protein, Human (His) is 487 a.a., with molecular weight of ~55 kDa.

HY-P77258A

	TRXR1/TXNRD1 Protein, Human (N-His) Thioredoxin reductase 1, cytoplasmic; GRIM-12; Thioredoxin reductase TR1; TR; KDRF	Human	E. coli
	The homodimeric flavoprotein TRXR1/TXNRD1 plays a key role in cellular redox regulation, growth and differentiation. It reduces the disulfide protein thioredoxin (Trx) to its dithiol-containing form and exhibits reductase activity towards hydrogen peroxide (H2O2). TRXR1/TXNRD1 Protein, Human (N-His) is the recombinant human-derived TRXR1/TXNRD1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TRXR1/TXNRD1 Protein, Human (N-His) is 487 a.a., with molecular weight of ~60 kDa.

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HY-P82570

	Thioredoxin Reductase 1 Antibody (YA2315) TR; TR1; TXNR; TrxR1; GRIM-12	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	Thioredoxin Reductase 1 Antibody (YA2315) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2315), targeting Thioredoxin Reductase 1, with a predicted molecular weight of 71 kDa (observed band size: 55 kDa). Thioredoxin Reductase 1 Antibody (YA2315) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse background.

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TrxR1

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