LW-216

Cat. No.: HY-163724: FAQs
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LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.

For research use only. We do not sell to patients.

LW-216 Chemical Structure

CAS No. : 2146090-18-6

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Description

LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity^[1].

In Vitro

LW-216 (5-25 μM, 24 h) selectively downregulates TrxR1 protein levels and induce apoptosis in NCI-H460 and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	NCI-H460, A549
Concentration:	5, 15, 25 μM
Incubation Time:	24 h
Result:	Reduced TrxR1 expression in both cell lines. Decreased the protein level of Bcl-2, PARP1 and Caspase-9, while increased Bax.

In Vivo

LW-216 (8 mg/kg, intravenously, once every two days for 18 days) inhibits tumor growth of NCI-H460 cells in a xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NCI-H460 cells in a xenograft mice model^[1]
Dosage:	8 mg/kg, once every two days for 18 days
Administration:	i.v.
Result:	Reduced bioluminescence intensity. Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.

Molecular Weight

485.57

Formula

C₃₀H₃₁NO₅

CAS No.

2146090-18-6

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang R, et al. Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. Neoplasia. 2024 Jul;53:101004 [Content Brief]

LW-216 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LW-2162146090-18-6LW216LW 216TrxRApoptosisThioredoxin ReductaseInhibitorNCI-H460A549anti-tumorinhibitorinhibit

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