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Tyrosinase inhibition

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (16) AMPK (1) CDK (1) Fungal (1) Isotope-Labeled Compounds (1) NF-κB (1) Parasite (1) PPAR (1)
By Research Areas:	Cancer (7) Infection (2) Inflammation/Immunology (1) Metabolic Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125762

Tyrosinase-IN-16	Tyrosinase	Cancer
Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM .

HY-N12427

Litchinol B	Tyrosinase	Cancer
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .

HY-156370

Tyrosinase-IN-15	Tyrosinase	Cancer
Tyrosinase-IN-15 (Compound 39) is a *tyrosinase* inhibitor (IC₅₀: 7.12 μM, K_i: 11.8 μM) .

HY-W552702

Tyrosinase-IN-29	Tyrosinase	Metabolic Disease
Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC₅₀: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation .

HY-162889

Tyrosinase-IN-36	Tyrosinase	Others
Tyrosinase-IN-36 is a moderate *Tyrosinase* inhibitor, with an inhibition percentage of 42.75% at 100 μM compared to kojic acid, and it exhibits antioxidant activity .

HY-N3425

Kazinol U	AMPK	Others
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-117761

MHY908	PPAR	Metabolic Disease Cancer
MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

HY-N1658

2,3-Dihydroisoginkgetin	Tyrosinase	Others
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of *Tyrosinase, with 36.84% inhibition* at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

HY-W050154R

Kojic acid (Standard)	Parasite Tyrosinase NF-κB CDK	Infection Inflammation/Immunology Cancer
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

HY-133680

β-Tocopherol	Tyrosinase	Metabolic Disease
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-155240

Tyrosinase-IN-13	Tyrosinase	Cancer
Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC₅₀=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10) .

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-126618

Aspochalasin I	Tyrosinase	Cancer
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of *tyrosinase*, and can thus be used as whitening agent .

HY-113068S

β-Tocopherol-d3	Isotope-Labeled Compounds Tyrosinase	Metabolic Disease
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-133680R

β-Tocopherol (Standard)	Tyrosinase	Metabolic Disease
β-Tocopherol (Standard) is the analytical standard of β-Tocopherol. This product is intended for research and analytical applications. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-113068R

(rel)-β-Tocopherol (Standard)	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Tyrosinase	Others
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis *tyrosinase* inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133680

β-Tocopherol	Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Plants Palmae Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl.	Tyrosinase
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-113068

(rel)-β-Tocopherol	Structural Classification Monophenols Microorganisms Classification of Application Fields Agrostidoideae Source classification Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Tyrosinase
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N12427

Litchinol B	Structural Classification Monophenols Litchi Chinensis Sonn. Source classification Sapindaceae Phenols Plants	Tyrosinase
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .

HY-N3425

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-N1658

2,3-Dihydroisoginkgetin	Podocarpus macrophyllus (Thunb.) Sweet Flavonoids Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Podocarpaceae Biflavones Disease Research Fields	Tyrosinase
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of *Tyrosinase, with 36.84% inhibition* at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

HY-W050154R

Kojic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Parasite Tyrosinase NF-κB CDK
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .

HY-N10219

Dihydroaltenuene B	Infection Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Tyrosinase Fungal
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

HY-126618

Aspochalasin I	Structural Classification Natural Products Source classification Ericameria laricifolia (A.Gray) Shinners Plants Compositae	Tyrosinase
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of *tyrosinase*, and can thus be used as whitening agent .

HY-133680R

β-Tocopherol (Standard)	Structural Classification Monophenols Source classification Phenols Palmae Plants Trachycarpus fortunei (Hook.) H. Wendl.	Tyrosinase
β-Tocopherol (Standard) is the analytical standard of β-Tocopherol. This product is intended for research and analytical applications. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-113068R

(rel)-β-Tocopherol (Standard)	Structural Classification Monophenols Microorganisms Agrostidoideae Source classification Phenols Plants Triticum aestivum L.	Tyrosinase
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Structural Classification Terpenoids Source classification Pteridaceae Diterpenoids Plants Pteris semipinnata L. Sp.	Tyrosinase
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis *tyrosinase* inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

Cat. No.	Product Name	Chemical Structure

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

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Tyrosinase inhibition

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products