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Results for "

antipyretic effects

" in MedChemExpress (MCE) Product Catalog:

27

Inhibitors & Agonists

9

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1428
    2-Ethoxybenzamide

    Ethenzamide

    		 Epigenetic Reader Domain Inflammation/Immunology Cancer
    2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects . 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation .
    2-Ethoxybenzamide
  • HY-105808
    Furobufen

    		Others Neurological Disease Inflammation/Immunology
    Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue .
    Furobufen
  • HY-133588
    4-Formylaminoantipyrine

    		Endogenous Metabolite Metabolic Disease
    4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .
    4-Formylaminoantipyrine
  • HY-B1054
    Famprofazone

    		COX Inflammation/Immunology
    Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects.
    Famprofazone
  • HY-N0564
    Notopterol
    1 Publications Verification

    		 Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .
    Notopterol
  • HY-W040672
    Ibufenac

    Dytransin

    		 COX Inflammation/Immunology
    Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
    Ibufenac
  • HY-78131AS
    (S)-(+)-Ibuprofen D3

    (S)-Ibuprofen d3

    		 COX Inflammation/Immunology
    (S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].
    (S)-(+)-Ibuprofen D3
  • HY-B1428R
    2-Ethoxybenzamide (Standard)

    Ethenzamide (Standard)

    		 Epigenetic Reader Domain Inflammation/Immunology Cancer
    2-Ethoxybenzamide (Standard) is the analytical standard of 2-Ethoxybenzamide (HY-B1428). 2-Ethoxybenzamide (Ethenzamide) Standard is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects . 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation .
    2-Ethoxybenzamide (Standard)
  • HY-N12647
    cis-Hinkiresinol

    		Others Infection Inflammation/Immunology
    cis-Hinkiresinol is a bioactive constituent of Rhizoma anemarrhenae. Rhizoma anemarrhenae is reprted to have anti-pathogenic microorganism, hypoglycemic effects, anti-inflammatory, antipyretic effects and anti-platelet aggregation .
    cis-Hinkiresinol
  • HY-B1279AS
    Metamizole-d3 sodium

    Dipyrone-d3

    		 Isotope-Labeled Compounds COX Neurological Disease Inflammation/Immunology
    Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .
    Metamizole-d3 sodium
  • HY-133588R
    4-Formylaminoantipyrine (Standard)

    		Endogenous Metabolite Metabolic Disease
    4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .
    4-Formylaminoantipyrine (Standard)
  • HY-133588S
    4-Formylaminoantipyrine-d3

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    4-Formylaminoantipyrine-d3 is the deuterium labeled 4-Formylaminoantipyrine (HY-133588). 4-Formylaminoantipyrine is an excreted metabolite of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .
    4-Formylaminoantipyrine-d3
  • HY-W097858
    2-Hydroxy-4-methoxybenzoic acid potassium

    4-Methoxysalicylic acid potassium

    		 Tyrosinase Infection Metabolic Disease
    2-Hydroxy-4-methoxybenzoic acid (potassium), is one of the major phytoconstituents of Decalepis arayalpathra, also known as 4-Methoxysalicylic acid (potassium), has a variety of biological effects, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic properties .
    2-Hydroxy-4-methoxybenzoic acid potassium
  • HY-N0564R
    Notopterol (Standard)

    		Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Notopterol (Standard) is the analytical standard of Notopterol. This product is intended for research and analytical applications. Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .
    Notopterol (Standard)
  • HY-78131A
    (S)-(+)-Ibuprofen

    Dexibuprofen

    		 COX Inflammation/Immunology Cancer
    (S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects .
    (S)-(+)-Ibuprofen
  • HY-13913
    NS-398
    Maximum Cited Publications
    16 Publications Verification

    		 COX Inflammation/Immunology Cancer
    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
    NS-398
  • HY-105142
    M-5011

    		COX Inflammation/Immunology
    M-5011 is a potent and orally active anti-inflammatory agent. M-5011 shows potent antinociceptive effects and inhibits kaolin (HY-W115786)-induced writhing. M-5011 decreases peritoneal 6-keto-PGF1 alpha levels with low ulcerogenic activities. M-5011 shows anti-inflammatory and anti-pyretic effects and analgesic effect .
    M-5011
  • HY-N15147
    Panax saponin C

    		DNA/RNA Synthesis Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .
    Panax saponin C
  • HY-103387
    DuP-697

    		COX Apoptosis Inflammation/Immunology Cancer
    DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC50 of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC50 of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects .
    DuP-697
  • HY-78131AR
    (S)-(+)-Ibuprofen (Standard)

    		COX Inflammation/Immunology
    (S)-(+)-Ibuprofen (Standard) is the analytical standard of (S)-(+)-Ibuprofen. This product is intended for research and analytical applications. (S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects .
    (S)-(+)-Ibuprofen (Standard)
  • HY-N1746
    (2S)-2'-Methoxykurarinone

    2'-O-Methylkurarinone

    		 RANKL/RANK Metabolic Disease Inflammation/Immunology Cancer
    (2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .
    (2S)-2'-Methoxykurarinone
  • HY-N3945
    Glaucine

    O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396

    		 Phosphodiesterase (PDE) Calcium Channel MMP NF-κB Inflammation/Immunology Cancer
    Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a Ki of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .
    Glaucine
  • HY-B1138
    Fenbufen
    1 Publications Verification

    CL-82204

    		 COX Caspase Inflammation/Immunology
    Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .
    Fenbufen
  • HY-B1138R
    Fenbufen (Standard)

    		COX Caspase Inflammation/Immunology
    Fenbufen (Standard) is the analytical standard of Fenbufen. This product is intended for research and analytical applications. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .
    Fenbufen (Standard)
  • HY-B1138S
    Fenbufen-d9

    		Isotope-Labeled Compounds COX Caspase Inflammation/Immunology
    Fenbufen-d9 (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
    Fenbufen-d9
  • HY-B0367
    Lornoxicam

    Chlortenoxicam; Ro 13-9297

    		 Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor Inflammation/Immunology Cancer
    Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC50=0.005 μM; COX-2:IC50=0.008 μM) and inhibits the production of NO by iNOS (IC50=65 μM) and the proinflammatory cytokine IL-6 (IC50=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .
    Lornoxicam
  • HY-169430
    AGU654

    		PGE synthase
    AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC50 of 2.9 nM against mPGES-1. AGU654 inhibits mPGES-1 to block the pathway converting arachidonic acid into prostaglandin E2 (PGE2) by COX-1/2, thereby alleviating inflammatory responses, pain, and fever. In activated human monocyte-derived macrophages and human whole blood models, AGU654 selectively suppresses bacterial exotoxin-induced PGE2 production while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, exhibiting excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a strategy for studying inflammatory diseases and pain .
    AGU654

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