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PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependentproteinkinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice .
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependentproteinkinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable proteinkinase inhibitor .
HA-100 is a potent proteinkinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependentproteinkinase (PKG), cAMP-dependentproteinkinase (PKA), proteinkinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor .
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependentproteinkinase. PKI (5-24),amide is a potent cAMP-dependentproteinkinase (PKA) (PKA) inhibitor with a Ki of 2.3 nM .
PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependentproteinkinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice .
8-HA-cAMP is a membrane-permeable cAMP analogue and an activator of cAMP-dependentproteinkinase and PKA I. 8-HA-cAMP exerts metabolic stability towards mammalian cyclic nucleotide-responsive phosphodiesterases .
HA-100 hydrochloride is a potent proteinkinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependentproteinkinase (PKG), cAMP-dependentproteinkinase (PKA), proteinkinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor .
HA-100 dihydrochloride is a potent proteinkinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependentproteinkinase (PKG), cAMP-dependentproteinkinase (PKA), proteinkinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor .
2-Cl-cAMP is an analog of cAMP and a potent stimulator of cAMP-dependentproteinkinases such as PKA type I and II. 2-Cl-cAMP can be used as starting material for cyclic nucleotides .
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependentproteinkinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable proteinkinase inhibitor .
2-AHA-cAMP is an analogue of natural signal molecule cAMP and an activator of cAMP-dependentproteinkinase. 2-AHA-cAMP has a free terminal primary amino group, which can be used for coupling to gels or fluorescent dyes .
6-Bn-cAMP is a site-selective activator of cAMP-dependentproteinkinase (PKA) which does not activate Epac. 6-Bn-cAMP increases hydrolytic stability against PDE, esterases, amidases and considerably higher membrane permeability compared to cAMP .
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependentproteinkinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependentproteinkinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM .
Sp-8-PIP cAMP sodium is a non-corresponding isomer of 8-Piperidino-cAMP. 8-Piperidino-cAMP binds with high affinity to site A of the regulatory subunit of cAMP-dependentproteinkinase type I (AI). Sp-8-PIP cAMP sodium can be used as an antagonist of cAMP-induced activation .
Sp-6-Phe-cAMPS is a potent, site-selective and membrane-permeable activator of cAMP-dependentproteinkinase. Sp-6-Phe-cAMPS does not activate exchange factors directly activated by cAMP and can therefore be used as an Epac negative control. Sp-6-Phe-cAMPS can be used in the study of neurodegenerative diseases .
RG 14921, a compound structurally related to erbstatin, was investigated for its mechanism of inhibition of epidermal growth factor (EGF) receptor tyrosine kinase and CAMP-dependentkinase activity by kinetic analysis. Both compounds are slow-binding inhibitors of EGF receptor kinase. Erbstatin inhibits EGF receptor kinase as a partially competitive inhibitor relative to ATP and peptide substrates, suggesting that it binds at different positions in the enzyme's ATP- and peptide substrate-binding sites, thereby reducing the enzyme's binding affinity for both substrates. In contrast, the derivative RG 14921 inhibits EGF receptor kinase activity as a noncompetitive inhibitor relative to ATP and peptide substrates. Structurally related compounds exhibit different modes of inhibition, suggesting that the catalytic center of the receptor kinase domain may have a dynamic and possibly extended structure. Erbstatin and RG 14921 exerted similar effects on CAMP-dependentproteinkinase activity. In this system, both compounds exhibited strong inhibition and acted in a competitive inhibition manner with ATP and a noncompetitive inhibition manner with peptide substrates.
8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependentproteinkinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .
Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependentproteinkinases(cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets .
Sp-5,6-DCl-cBIMPS sodium is a potent and specific cAMP-dependentproteinkinases(cAMP-PK) activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets .
8-CPT-cAMP-AM is a highly membrane-permeant analogue of signal molecule cAMP. 8-CPT-cAMP-AM is an activator of cAMP- and cGMP-dependentproteinkinases and of Epac (exchange protein activated by cAMP) .
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependentproteinkinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependentproteinkinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependentproteinkinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependentproteinkinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice .
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependentproteinkinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable proteinkinase inhibitor .
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependentproteinkinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependentproteinkinase. PKI (5-24),amide is a potent cAMP-dependentproteinkinase (PKA) (PKA) inhibitor with a Ki of 2.3 nM .
PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependentproteinkinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice .
Kemptide (amide) is a heptapeptide with properties of a cytophilic substrate. Kemptide is a molecule preserving cell membrane intactness, is phosphorylated by PKI, the inhibitory protein specific for cAMP-dependentproteinkinase (PK) .
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependentproteinkinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable proteinkinase inhibitor .
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependentproteinkinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM .
The PKI-β protein emerged as an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity. This protein operates at the molecular level, binding to the catalytic subunit of the enzyme after cAMP induces dissociation of its regulatory chain. PKI-beta Protein, Human (His) is the recombinant human-derived PKI-beta protein, expressed by E. coli , with N-6*His labeled tag.
PKACα protein is a key kinase that phosphorylates a variety of substrates, including CDC25B, ABL1, NFKB1, and VASP, affecting a variety of cellular processes, such as cell cycle progression, platelet regulation, and adipogenic differentiation. It also negatively regulates mTORC1 through RPTOR phosphorylation, thereby modulating signaling networks. PKACα Protein, Human (Sf9, GST) is the recombinant human-derived PKACα protein, expressed by Sf9 insect cells , with GST tagged. The total length of PKACα Protein, Human (Sf9, GST) is 350 a.a., .
PRKX is an important serine/threonine kinase that mediates cAMP signaling and phosphorylates targets such as CREB, SMAD6, and PKD1. It regulates myeloid cell differentiation through SMAD6 phosphorylation, promotes nephrogenesis by enhancing renal epithelial cell migration and tubulogenesis, and actively promotes angiogenesis by affecting endothelial cell proliferation and migration. PRKX Protein, Human (Sf9, GST) is the recombinant human-derived PRKX protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PRKX Protein, Human (Sf9, GST) is 358 a.a., .
PRKAR1A protein is a regulatory subunit of cAMP-dependent protein kinase that mediates cellular responses to cAMP signaling.The inactive holoenzyme has two regulatory chains and two catalytic chains.PRKAR1A Protein, Mouse (sf9, His) is the recombinant mouse-derived PRKAR1A protein, expressed by Sf9 insect cells , with C-His labeled tag.
PRKAR2A; PKR2; PRKAR2; cAMP-dependentproteinkinase type II-alpha regulatory subunit
WB, IHC-P, ICC/IF, IP
Human, Mouse, Rat, Pig
Phospho-PKA RII alpha (Ser99) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 46 kDa, targeting to Phospho-PKA RII alpha (Ser99). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Pig.
PKA alpha + beta Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-PKA alpha + beta polyclonal antibody. PKA alpha + beta Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat background without labeling.
PKA C gamma Antibody (YA1726) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1726), targeting PKA C gamma, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). PKA C gamma Antibody (YA1726) can be used for WB, IP experiment in human, mouse, rat background.
PKA RI alpha Antibody (YA1751) is a biotin-conjugated non-conjugated IgG antibody, targeting PKA RI alpha, with a predicted molecular weight of 43 kDa (observed band size: 43 kDa). PKA RI alpha Antibody (YA1751) can be used for WB experiment in human, rat background.
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependentproteinkinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependentproteinkinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
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