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Results for "

collagenases

" in MedChemExpress (MCE) Product Catalog:

48

Inhibitors & Agonists

9

Peptides

15

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2661
    FA-Leu-Gly-Pro-Ala-OH

    		Biochemical Assay Reagents Others
    FA-Leu-Gly-Pro-Ala-OH is a substrate of microbial collagenase .
    FA-Leu-Gly-Pro-Ala-OH
  • HY-100210A
    FN-439 TFA

    		MMP Inflammation/Immunology Cancer
    FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation .
    FN-439 TFA
  • HY-P2641
    Peptide 74

    		MMP Cancer
    Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .
    Peptide 74
  • HY-137521
    Z-PDLDA-NHOH

    		MMP Others
    Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase .
    Z-PDLDA-NHOH
  • HY-P4474
    Pz-Pro-Leu-Gly-Pro-d-Arg

    		Bacterial Infection
    Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .
    Pz-Pro-Leu-Gly-Pro-d-Arg
  • HY-100210
    FN-439

    		MMP Inflammation/Immunology Cancer
    FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation .
    FN-439
  • HY-N3654
    Cyclo(l-Pro-d-Leu)

    		Tyrosinase Others
    Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect .
    Cyclo(l-Pro-d-Leu)
  • HY-123886
    Aranciamycin

    		Antibiotic Cancer
    Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC503.7*10-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells .
    Aranciamycin
  • HY-N1235
    Skullcapflavone I

    Panicolin

    		 Elastase MicroRNA Cancer
    Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .
    Skullcapflavone I
  • HY-125422
    Matlystatin A

    		Aminopeptidase Cancer
    Matlystatin A is a potent aminopeptidase inhibitor, with IC50 values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .
    Matlystatin A
  • HY-O0004
    Collagenase I, from Clostridium histolyticum

    		MMP Metabolic Disease
    Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.
    Collagenase I, from Clostridium histolyticum
  • HY-E70005J
    Collagenase, Type VII

    Type VII collagenase

    		 MMP Neurological Disease
    Collagenase, Type VII (EC 3.4.24.3) is a collagenase that can be used to induce thalamic hemorrhage .
    Collagenase, Type VII
  • HY-E70369
    Collagenase H (Recombinant)

    		Biochemical Assay Reagents Others
    Collagenase H Recombinant is able to digest and break down collagen (especially collagen III) in the extracellular matrix (ECM). Collagenase H Recombinant is important in the isolation and function of rat pancreatic islets. Collagenase H Recombinant can be used in tissue engineering and cell culture .
    Collagenase H (Recombinant)
  • HY-E70005I
    Collagenase, Type VI

    Type VI collagenase

    		 MMP Cancer
    Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes .
    Collagenase, Type VI
  • HY-122624
    MMP13-IN-2

    		MMP Inflammation/Immunology
    MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .
    MMP13-IN-2
  • HY-E70005H
    Collagenase, Type VIII

    		Proteasome Cardiovascular Disease
    Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis .
    Collagenase, Type VIII
  • HY-E70005A
    Collagenase, Type I
    2 Publications Verification

    EC 3.4.24.3

    		 MMP Others
    Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .
    Collagenase, Type I
  • HY-E70005B
    Collagenase, Type II
    2 Publications Verification

    		 MMP Others
    Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .
    Collagenase, Type II
  • HY-E70005E
    Collagenase, Type V

    		MMP Others
    Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .
    Collagenase, Type V
  • HY-122106
    RS-104966

    		MMP Others
    RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1 .
    RS-104966
  • HY-116399
    MMP-2/MMP-9-IN-1

    		MMP Cancer
    MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .
    MMP-2/MMP-9-IN-1
  • HY-E70005C
    Collagenase, Type III

    		MMP Others
    Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin
    Collagenase, Type III
  • HY-E70005D
    Collagenase IV, Clostridium histolytica

    Collagenase, Type IV

    		 MMP Others
    Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.
    Collagenase IV, Clostridium histolytica
  • HY-P2718
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH

    		Biochemical Assay Reagents Others
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is a collagenase substrate that induces planulae to settle .
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH
  • HY-P4931
    Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

    Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

    		 MMP Cancer
    Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
    Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
  • HY-19677
    Cipemastat

    Ro 32-3555

    		 MMP Cancer
    Cipemastat is a potent, competitive inhibitor of human collagenases 1, 2 and 3 with Kis of 3.0, 4.4 and 3.4 nM, respectively.
    Cipemastat
  • HY-E70368
    Collagenase G (Recombinant)

    		Biochemical Assay Reagents Others
    Collagenase G Recombinant is involved in the islet isolation process, and digests specific collagens from the N-terminus, especially Col-V .
    Collagenase G (Recombinant)
  • HY-P10139
    Dnp-PLGLWAr-NH2

    		MMP Others
    Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .
    Dnp-PLGLWAr-NH2
  • HY-16182A
    Ecamsule disodium

    		Biochemical Assay Reagents Others
    Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .
    Ecamsule disodium
  • HY-N0136
    Taxifolin
    10+ Cited Publications

    (+)-Dihydroquercetin; (+)-Taxifolin

    		 TNF Receptor Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    Taxifolin
  • HY-131577
    Neutral protease, Paenibacillus polymyxa
    1 Publications Verification

    Dispase II, Dispase

    		 Endogenous Metabolite Metabolic Disease
    Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .
    Neutral protease, Paenibacillus polymyxa
  • HY-N2472
    Medicagenic acid

    Castanogenin

    		 Bacterial Infection
    Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .
    Medicagenic acid
  • HY-N0136A
    (±)-Taxifolin

    (±)-Dihydroquercetin

    		 Autophagy Tyrosinase Inflammation/Immunology
    (±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (±)-Taxifolin
  • HY-N0136B
    (-)-Taxifolin

    (-)-Dihydroquercetin

    		 Tyrosinase Inflammation/Immunology
    (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (-)-Taxifolin
  • HY-16182
    Ecamsule

    		Biochemical Assay Reagents Others
    Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule
  • HY-N0646
    Silydianin
    1 Publications Verification

    		 Phosphatase Endogenous Metabolite Cancer
    Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products .
    Silydianin
  • HY-N0136S
    Taxifolin-d3

    (+)-Dihydroquercetin-d3; (+)-Taxifolin-d3

    		 Isotope-Labeled Compounds Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
    Taxifolin-d3
  • HY-N0136R
    Taxifolin (Standard)

    		TNF Receptor Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin (Standard) is the analytical standard of Taxifolin. This product is intended for research and analytical applications. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    Taxifolin (Standard)
  • HY-15768
    Ilomastat
    Maximum Cited Publications
    40 Publications Verification

    GM6001; Galardin

    		 MMP Cancer
    Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
    Ilomastat
  • HY-15652
    Freselestat

    ONO-6818; ONO-PO-736

    		 Elastase Inflammation/Immunology
    Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity .
    Freselestat
  • HY-N2472R
    Medicagenic acid (Standard)

    		Bacterial Infection
    Medicagenic acid (Standard) is the analytical standard of Medicagenic acid. This product is intended for research and analytical applications. Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .
    Medicagenic acid (Standard)
  • HY-16182R
    Ecamsule (Standard)

    		Biochemical Assay Reagents Others
    Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule (Standard)
  • HY-15652A
    Freselestat quarterhydrate

    ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate

    		 Elastase Inflammation/Immunology
    Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity .
    Freselestat quarterhydrate
  • HY-N12742
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside

    		Others Inflammation/Immunology
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside
  • HY-N0646R
    Silydianin (Standard)

    		Phosphatase Endogenous Metabolite Cancer
    Silydianin (Standard) is the analytical standard of Silydianin. This product is intended for research and analytical applications. Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38?μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products .
    Silydianin (Standard)
  • HY-N0136S1
    (±)-Taxifolin-13C3

    (±)-Dihydroquercetin-13C3

    		 Autophagy Tyrosinase Inflammation/Immunology
    (±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (±)-Taxifolin-13C3
  • HY-N2038
    3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone

    		Phosphodiesterase (PDE) Neurological Disease Cancer
    3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .
    3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone
  • HY-N2038R
    3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone (Standard)

    		Phosphodiesterase (PDE) Neurological Disease Cancer
    3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone (Standard) is the analytical standard of 3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone. This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .
    3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone (Standard)

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