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Results for "

diABZI

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162874
    diABZI-V/C-DBCO

    		STING Inflammation/Immunology Cancer
    diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research .
    diABZI-V/C-DBCO
  • HY-112921A
    diABZI STING agonist-1
    Maximum Cited Publications
    30 Publications Verification

    		 STING Inflammation/Immunology
    diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride
    Maximum Cited Publications
    30 Publications Verification

    		 STING Inflammation/Immunology Cancer
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 trihydrochloride
  • HY-137320
    diABZI-C2-NH2

    		STING Cancer
    diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist .
    diABZI-C2-NH2
  • HY-103665
    STING agonist-3
    5+ Cited Publications

    		 STING Cancer
    STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
    STING agonist-3
  • HY-123943
    STING agonist-4
    5 Publications Verification

    		 STING Cancer
    STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .
    STING agonist-4
  • HY-168034
    diABZI-4

    		STING Infection Inflammation/Immunology
    diABZI-4 is an oral active STING agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC50 range of 11.8-199 nM .
    diABZI-4
  • HY-164278
    diABZI-V/C-Mal

    		Ligands for Target Protein for PROTAC STING Cancer
    diABZI-V/C-Mal is a STING agonist.
    diABZI-V/C-Mal
  • HY-112921
    diABZI STING agonist-1 (tautomerism)

    		STING Inflammation/Immunology
    diABZI STING agonist-1 tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 (tautomerism)
  • HY-158048
    UNC9036

    		PROTACs STING Inflammation/Immunology
    UNC9036 is a PROTAC-based STING degrader, with a DC50 of 227 nM. UNC9036-mediated STING degradation is proteasome and VHL dependent (Structure Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker) .
    UNC9036

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