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Results for "

dogs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Adrenergic Receptor (2) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) ATP Synthase (1) Bacterial (2) BCRP (1) Calcium Channel (2) Chloride Channel (2) COX (3) CXCR (1) Dopamine Receptor (2) Endogenous Metabolite (1) Endothelin Receptor (1) FABP (1) Fluorescent Dye (1) GABA Receptor (2) HBV (1) HCV (1) HCV Protease (1) Histamine Receptor (4) HIV (2) HIV Integrase (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (1) LRRK2 (1) mAChR (4) Microsomal Triglyceride Transfer Protein (MTP) (1) P-glycoprotein (1) Parasite (7) Potassium Channel (3) Progesterone Receptor (1) Prostaglandin Receptor (3) Renin (1) Sigma Receptor (1) Sodium Channel (1) Trk Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (14) Endocrinology (3) Infection (16) Inflammation/Immunology (15) Metabolic Disease (5) Neurological Disease (23)

By Targets:

5-HT Receptor (7)

Adrenergic Receptor (2)

Aminopeptidase (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

ATP Synthase (1)

Bacterial (2)

BCRP (1)

Calcium Channel (2)

Chloride Channel (2)

COX (3)

CXCR (1)

Dopamine Receptor (2)

Endogenous Metabolite (1)

Endothelin Receptor (1)

FABP (1)

Fluorescent Dye (1)

GABA Receptor (2)

HBV (1)

HCV (1)

HCV Protease (1)

Histamine Receptor (4)

HIV (2)

HIV Integrase (1)

Integrin (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

LRRK2 (1)

mAChR (4)

Microsomal Triglyceride Transfer Protein (MTP) (1)

P-glycoprotein (1)

Parasite (7)

Potassium Channel (3)

Progesterone Receptor (1)

Prostaglandin Receptor (3)

Renin (1)

Sigma Receptor (1)

Sodium Channel (1)

Trk Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (14)

Endocrinology (3)

Infection (16)

Inflammation/Immunology (15)

Metabolic Disease (5)

Neurological Disease (23)

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0962

Piperidolate hydrochloride	mAChR	Neurological Disease
Piperidolate hydrochloride is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-B0962A

Piperidolate	mAChR	Neurological Disease
Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-B0915

Orbifloxacin 1 Publications Verification CP-104354	Bacterial Antibiotic	Infection
Orbifloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic which is approved for use in dogs.

HY-17597

Febantel	Parasite	Infection
Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.

HY-113797

RS-52367	Others	Others
RS-52367 is a potent syntex β-adrenergic antagonist. RS-52367 decreases intraocular pressure with a mild systemic effect in dogs .

HY-122349

Lotrifen L-12717	Others	Others
Lotrifen is a non-hormonal compound with abortifacient effects. Lotrifen is most effective when used on the 20th day of pregnancy in beagle and mongrel dogs .

HY-116183

ITX 4520	HCV	Infection
ITX 4520 is an orally active and potent hepatitis C virus entry inhibitor exhibiting an excellent PK profile in both rats and dogs .

HY-119722

Butafosfan	Others	Others
Butafosfan is a phosphate containing compound, which is used as active ingredient of veterinary drug. Butafosfan can stimulate the appetite, immune system and digestive function, improves liver and muscle function of dogs. Butafosfan can mitigate the adverse effects of Dexamethasone (HY-14648) on liver and pancreatic function in dogs .

HY-119447S

Mavacoxib-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs[1].

HY-W181626

Tiprenolol DU 21445	5-HT Receptor	Cardiovascular Disease
Tiprenolol is a β-adrenoceptor blocker. Tiprenolol can abolish the ventricular arrhythmias produced by adrenaline in dogs respired with halothane .

HY-U00070

Dirlotapide CP742033; Slentrol	Microsomal Triglyceride Transfer Protein (MTP)	Metabolic Disease
Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.

HY-118370

MF-592	Prostaglandin Receptor	Inflammation/Immunology
MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

HY-123429

CK0683A	Others	Infection
CK0683A is a novel biaminourea antibiotic with antiplaque effects and demonstrated efficacy in experimental mouse dental disease models. A 12-week study in beagles compared its efficacy in terms of plaque and gingivitis reduction, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease is similar to that of humans. As a positive control for plaque and gingivitis reduction and staining, chlorhexidine acetate was selected because it is effective in both humans and dogs.

HY-159115

ART26.12	FABP	Metabolic Disease
ART26.12 is an orally active and selective FABP5 inhibitor. ART26.12 has a high oral bioavailability in rats and dogs .

HY-123479

CK0492B	Others	Infection
CK0492B is a novel biaminourea antibiotic that has antiplaque properties in vitro and has shown efficacy in an experimental mouse dental disease model. A 12-week study in beagles compared its efficacy in reducing plaque and gingivitis, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease are similar to humans. Chlorhexidine acetate was selected as a positive control for plaque and gingivitis reduction and staining because it is effective in both humans and dogs.

HY-P99301

Lokivetmab Anti-Canine IL31 Recombinant Antibody	Interleukin Related	Inflammation/Immunology
Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody that can be used for the research of atopic dermatitis (AD) in dogs .

HY-114682A

Lenperone hydrochloride AHR 2277	Dopamine Receptor	Neurological Disease
Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research .

HY-118934

Novocebrin	Others	Neurological Disease Metabolic Disease
Novocebrin is a central nervous system activator that effectively increases brain and femoral blood flow in dogs. In addition, Novocebrin inhibits triglyceride biosynthesis in porcine adipose tissue .

HY-W019720

1-Methylguanidine hydrochloride	Endogenous Metabolite	Inflammation/Immunology
1-Methylguanidine hydrochloride is a uremic toxin, which accumulate in dogs with renal failure and chronic kidney disese. 1-Methylguanidine hydrochloride enhances the oxidative metabolism and induces apoptosis in neutrophils .

HY-119595

Haloperidide R3201	Others	Neurological Disease
Haloperidide (R3201) is a neuroleptic compound. Haloperidide is a potent and selective anti-emetic agent. Haloperidide antagonizes Apomorphine (HY-12723)-induced emesis in dogs .

HY-121460

Spiraprilat	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF) .

HY-118770

Nafetolol K 5407 free base	Adrenergic Receptor	Cardiovascular Disease
Nafetolol (K 5407), specifically effective on cardiac (β1)-adrenoceptors, is an orally active β blocking agent, with a t_1/2 of ~ 2 h in dogs .

HY-B0519C

Tylosin lactate	Bacterial	Infection
Tylosin (lactate) is an anti-bacterial agent that can target spore-forming bacteria. Tylosin (lactate) can increase the levels of Enterococcus and lactobacilli in dogs' feces and help relieve tylosin-responsive diarrhea .

HY-103149

SB-216641A SB-216641 hydrochloride	5-HT Receptor	Neurological Disease
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT_1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT_1B receptors over h5-HT_1D receptors. SB-216641A inhibits the function of SKF-99101H .

HY-108582

Y-27152	Potassium Channel	Cardiovascular Disease
Y-27152, a proagent of the K_ATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state .

HY-118033

SQ 30774	Renin	Cardiovascular Disease
SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo .

HY-102092

FR139317 PD 147953	Endothelin Receptor	Cardiovascular Disease
FR139317 (PD 147953) is a selective ET_A receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs .

HY-118311

(Z)-W 3699 (Z)-Probilin; (Z)-Secrebil; (Z)-Piprozolin	Others	Metabolic Disease
(Z)-W 3699 is a potential choleretic. (Z)-W 3699 can increase the solubility of cholesterol in the gallbladder by altering the secretion of micellar bile acids. (Z)-W 3699 can prevent the formation of cholesterol-containing gallstones in dogs.

HY-B0770

Artemotil β-Arteether; (+)-Arteether; Arteether	CXCR Parasite	Infection Cancer
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-119447

Mavacoxib	COX	Inflammation/Immunology
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-126762

Fenprostalene	Progesterone Receptor	Endocrinology
Fenprostalene is an analog of Dinoprost (PGF2α) (HY-12956) that is used in veterinary medicine to induce corpus luteum regression and blood Progesterone (HY-N0437) levels reduction in dogs. Fenprostalene is potent in ameliorating pyometra and inducing abortion .

HY-16974

Afoxolaner	GABA Receptor Chloride Channel Parasite	Infection
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod .

HY-123284

LY137150	Others	Others
LY137150 (2) and LY163252 (4) are products of LY175326 metabolism in rats or dogs. The preparation of LY175326 labeled with 14C at the methylthiol group provides a sensitive method to determine whether the metabolically produced LY137150 (2) is further metabolized by S-demethylation.

HY-12159

MK-0668	Integrin	Inflammation/Immunology
MK-0668 is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC₅₀) of 0.13 nM in human whole blood. And MK-0668 exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats .

HY-16730

Sarolaner PF-6450567	Parasite	Infection
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC₈₀ value of 0.3 μg/mL against C. felis and a LC₁₀₀ value of 0.003 μg/mL against O. turicata .

HY-100516

Cimicoxib UR-8880	COX	Inflammation/Immunology
Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .

HY-P99297

Bedinvetmab ZTS-00508841	Trk Receptor	Inflammation/Immunology
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .

HY-17465R

Glycopyrrolate (Standard)	mAChR	Neurological Disease Cancer
Glycopyrrolate (Standard) is the analytical standard of Glycopyrrolate. This product is intended for research and analytical applications. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases .

HY-17465

Glycopyrrolate 1 Publications Verification Glycopyrronium bromide; Glycopyrrolate bromide	mAChR	Neurological Disease Cancer
Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases .

HY-156684

GDC-6599	TRP Channel	Neurological Disease
GDC-6599 is an orally active TRPA1 inhibitor, with IC₅₀ values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough .

HY-14466

GW 848687X	Prostaglandin Receptor	Endocrinology
GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain .

HY-116591

8-Iso-15-keto prostaglandin F2β	Others	Endocrinology
8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs .

HY-129445

SG-209	Potassium Channel	Cardiovascular Disease
SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs .

HY-149927

Antitumor agent-91	Others	Cancer
Antitumor agent-91 is a cyclic phosphate ester derivative with anticancer and anti-proliferative activities. Antitumor agent-91 has potential application in human castration resistant prostate cancer and pancreatic cancer .

HY-123328

AGN 191976	Prostaglandin Receptor	Cardiovascular Disease
AGN 191976 is a potent and selective thromboxane A₂-sensitive (TP) receptor agonist with EC₅₀ values of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A₂ in vascular function .

HY-111073

Bentysrepinine Y101	HBV	Infection Inflammation/Immunology
Bentysrepinine (Y101) is an orally active HBV inhibitor with anti-hepatitis B virus infection activity. Bentysrepinine exhibits favorable pharmacokinetic characteristics, with absolute bioavailability of 44.9%, 43.1%, and 19.2% in rats, dogs, and monkeys, respectively, and it does not accumulate in monkeys after 90 days of oral administration. Bentysrepinine is under research in the antiviral and hepatitis fields .

HY-129278

Lunarine	Parasite	Infection Cardiovascular Disease Neurological Disease
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-122229

GS-9822	HIV	Infection
GS-9822 is a potent antivira agent with nanomolar activity against wild-type HIV-1 viruses. GS-9822 potently inhibits the LEDGF/p75-integrase interaction with an IC₅₀ of 0.07 μM. GS-9822 has high in vitro metabolic stability and favorable oral pharmacokinetic profiles with low systemic clearance in rats, dogs, and monkeys .

HY-16773

Vedroprevir GS-9451	HCV Protease BCRP P-glycoprotein	Infection
Vedroprevir (GS-9451) is an inhibitor for HCV NS3/4A protease with an IC₅₀ of 3.2 nM. Vedroprevir is also an inhibitor for breast cancer resistant protein (BCRP) with an IC₅₀ of 1.4 μM. Vedroprevir inhibits P-gp, MRP1 and MRP2 with IC₅₀ of 34, 14.9 and 12 μM, respectively. Vedroprevir exhibits good pharmacokinetic characteristics in rats and dogs .

HY-118233

Alilusem potassium M 17055	Chloride Channel	Neurological Disease
Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle .

Cat. No.	Product Name	Type

HY-D0193

Ponceau 4R 1 Publications Verification Acid Red 18; New Coccine	Dyes
Ponceau 4R is a synthetic colorant that can be used for food coloring. Ponceau 4R is a strawberry red azo dye that can be used in a variety of foods, usually synthesized from aromatic hydrocarbons, and is stable to light, heat, and acids .

Cat. No.	Product Name	Target	Research Area