Nafetolol (Synonyms: K 5407 free base)

Cat. No.: HY-118770 Purity: 98.24%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nafetolol (K 5407), specifically effective on cardiac (β1)-adrenoceptors, is an orally active β blocking agent, with a t_1/2 of ~ 2 h in dogs.

For research use only. We do not sell to patients.

Nafetolol Chemical Structure

CAS No. : 42050-23-7

Size	Price	Stock	Quantity
1 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

Nafetolol (K 5407), specifically effective on cardiac (β1)-adrenoceptors, is an orally active β blocking agent, with a t_1/2 of ~ 2 h in dogs^[1].

Molecular Weight

319.44

Formula

C₁₉H₂₉NO₃

CAS No.

42050-23-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)(C)C)COC(C=C1)=C(C2CCC3CC2)C3=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 45 mg/mL (140.87 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1305 mL	15.6524 mL	31.3048 mL
5 mM	0.6261 mL	3.1305 mL	6.2610 mL
10 mM	0.3130 mL	1.5652 mL	3.1305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.24%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (247 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. G Goldaniga, et al. Pharmacokinetics and metabolism of a new beta-adrenergic blocking agent, the 1, ter-butyl-amino-3-(1,2,3,4-tetrahydro-1,4-ethano-8-hydroxy-5-naphthoxy)-2-propanol (K 5407). Eur J Drug Metab Pharmacokinet. 1980;5(1):9-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1305 mL	15.6524 mL	31.3048 mL	78.2620 mL
	5 mM	0.6261 mL	3.1305 mL	6.2610 mL	15.6524 mL
	10 mM	0.3130 mL	1.5652 mL	3.1305 mL	7.8262 mL
	15 mM	0.2087 mL	1.0435 mL	2.0870 mL	5.2175 mL
	20 mM	0.1565 mL	0.7826 mL	1.5652 mL	3.9131 mL
	25 mM	0.1252 mL	0.6261 mL	1.2522 mL	3.1305 mL
	30 mM	0.1043 mL	0.5217 mL	1.0435 mL	2.6087 mL
	40 mM	0.0783 mL	0.3913 mL	0.7826 mL	1.9565 mL
	50 mM	0.0626 mL	0.3130 mL	0.6261 mL	1.5652 mL
	60 mM	0.0522 mL	0.2609 mL	0.5217 mL	1.3044 mL
	80 mM	0.0391 mL	0.1957 mL	0.3913 mL	0.9783 mL
	100 mM	0.0313 mL	0.1565 mL	0.3130 mL	0.7826 mL

Nafetolol Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nafetolol42050-23-7K 5407K5407K-5407Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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