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Results for "

glomerular

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1472
    Deoxycorticosterone acetate
    2 Publications Verification

    11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate

    		 Mineralocorticoid Receptor Endogenous Metabolite Endocrinology
    Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .
    Deoxycorticosterone acetate
  • HY-112597A
    Mavodelpar

    REN001; HPP593

    		 PPAR Inflammation/Immunology
    Mavodelpar (REN001) is a selective PPARδ agonist. Mavodelpar suppresses glomerular injury and renal fibrosis. Mavodelpar can be used for the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD) . Mavodelpar is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mavodelpar
  • HY-P10279
    Anaritide

    Human atrial natriuretic factor (102–126)

    		 Natriuretic Peptide Receptor (NPR) Cardiovascular Disease Others
    Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival .
    Anaritide
  • HY-B0594
    Iohexol
    3 Publications Verification

    		 Autophagy Mitophagy Cancer
    Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .
    Iohexol
  • HY-101581
    Bucloxic acid

    804CB; Bucloxonic acid; Esfar

    		 Drug Derivative Inflammation/Immunology
    Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used for study of chronic glomerular nephropathies.
    Bucloxic acid
  • HY-101581A
    Bucloxic acid calcium

    804 CB calcium; Bucloxonic acid calcium; Esfar calcium

    		 Drug Derivative Inflammation/Immunology
    Bucloxic acid calcium is an anti-inflammatory pyrrazole derivative. Bucloxic acid calcium can be used for study of chronic glomerular nephropathies .
    Bucloxic acid calcium
  • HY-109071
    Relmapirazin

    MB-102

    		 Others Others
    Relmapirazin (MB-102) is a fluorescent tracer agent for real-time measurement of glomerular filtration rate .
    Relmapirazin
  • HY-113488
    8,9-Epoxyeicosatrienoic acid

    		Others Endocrinology
    8,9-Epoxyeicosatrienoic acid has an unique protective effect on glomeruli. 8,9-Epoxyeicosatrienoic acid blocks the increase in glomerular albumin permeability caused by circulating permeability factor (FSPF). 8,9-Epoxyeicosatrienoic acid can be used for the research of glomerular dysfunction .
    8,9-Epoxyeicosatrienoic acid
  • HY-169737
    Inulobiose

    		Glycosidase Amylases Metabolic Disease
    Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits α-glycosidase and α-amylase activities with IC50s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing .
    Inulobiose
  • HY-100446
    NTU281

    		Glutaminase Apoptosis Metabolic Disease Inflammation/Immunology
    NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes .
    NTU281
  • HY-10657
    SB-706375

    		Urotensin Receptor Cardiovascular Disease Others
    SB-706375 is an antagonist of the Urotensin II (UII) receptor. By blocking the Urotensin II receptor, SB-706375 reduces the kidney's response to UII and Urotensin-related peptide (URP) and significantly increases the Glomerular Filtration Rate (GFR). SB-706375 can be used in research on kidney diseases and hypertension .
    SB-706375
  • HY-B0594R
    Iohexol (Standard)

    		Autophagy Mitophagy Cancer
    Iohexol (Standard) is the analytical standard of Iohexol. This product is intended for research and analytical applications. Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker for the determination of glomerular filtration rate (GFR) at the level of renal function. Iohexol can be used for contrast in myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging .
    Iohexol (Standard)
  • HY-W341625
    Trihexosylceramide (d18:1/12:0)

    		Biochemical Assay Reagents Inflammation/Immunology
    Trihexosylceramide (d18:1/12:0) is a type of Trihexosylceramide. In the renal tissue of heterozygous Fabry's disease, the cytoplasm of glomerular epithelial cells appears foamy. Trihexosylceramide accumulated in glomerular epithelial cells as identified by immunostaining .
    Trihexosylceramide (d18:1/12:0)
  • HY-119035
    R-75317

    		Platelet-activating Factor Receptor (PAFR) Inflammation/Immunology
    R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis .
    R-75317
  • HY-B1472R
    Deoxycorticosterone acetate (Standard)
    2 Publications Verification

    11-Deoxycorticosterone acetate(Standard); DOC acetate(Standard); Cortexone acetate (Standard)

    		 Mineralocorticoid Receptor Endogenous Metabolite Endocrinology
    Deoxycorticosterone acetate (Standard) is the analytical standard of Deoxycorticosterone acetate. This product is intended for research and analytical applications. Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .
    Deoxycorticosterone acetate (Standard)
  • HY-134368
    Ap3A

    		Calcium Channel Cardiovascular Disease
    Ap3A is a vasoactive molecule that regulates intracellular Ca 2+ levels. Ap3A can promote the growth of vascular smooth muscle cells .
    Ap3A
  • HY-P99901
    Sibeprenlimab

    VIS649

    		 SARS-CoV Inflammation/Immunology Cancer
    Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .
    Sibeprenlimab
  • HY-14998
    Halofenate

    MK 185

    		 β-catenin PPAR Wnt Endocrinology
    Halofenate, structurally akin to clofibrate, was evaluated in hypertriglyceridemic patients over 6-week periods in a controlled, double-blind crossover trial. It effectively reduced serum triglycerides by 50%, with minimal impact on serum cholesterol levels. Additionally, it lowered serum uric acid by 30% and exhibited uricosuric effects independent of glomerular filtration rate. Halofenate was associated with a significant increase in plasma thyroxine (T4), accompanied by a decrease in protein-bound iodine and T4 by column. In vitro studies confirmed its ability to displace T4 from thyroid-binding proteins, suggesting a thyroxine-displacing effect, which could influence thyroid function in vivo .
    Halofenate
  • HY-101044
    PPADS tetrasodium
    4 Publications Verification

    		 P2X Receptor Na+/Ca2+ Exchanger Neurological Disease
    PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca 2+ exchanger in guinea pig airway smooth muscle .
    PPADS tetrasodium
  • HY-B2081
    Etozolin

    W-2900A

    		 Others Cardiovascular Disease Metabolic Disease
    Etozolin (W-2900A) is a diuretic agent. Etozolin inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin can be used in research of congestive heart failure, hypertension and edema .
    Etozolin
  • HY-B2081A
    Etozolin hydrochloride

    W-2900A hydrochloride

    		 Endogenous Metabolite Cardiovascular Disease Metabolic Disease
    Etozolin hydrochloride is a diuretic agent. Etozolin hydrochloride inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin hydrochloride can be used in research of congestive heart failure, hypertension and edema .
    Etozolin hydrochloride
  • HY-123572
    Bis-T-23

    AG1717

    		 Dynamin HIV Integrase Infection Metabolic Disease Inflammation/Immunology
    Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) .
    Bis-T-23
  • HY-102093A
    ZD 7155

    		Angiotensin Receptor Others
    ZD 7155 is an AT1R selective antagonist with renal function modulating activity. The effects of ZD 7155 on glomeruli and tubules were measured in 1- (N = 9) and 6-week-old (N = 13) lambs. Pretreatment with ZD 7155 after L-NAME infusion did not alter glomerular function in 1- or 6-week-old lambs. During postnatal development, Ang II modulates the effects of NO on electrolyte handling via AT1R and AT2R. In 6-week-old lambs, selective inhibition of AT1R and AT2R increased the excretion of Na+, K+, and Cl-. In 6-week-old lambs, pretreatment with ZD 7155 and PD 123319 followed by the addition of L-NAME increased urine flow rate by 200%, free water clearance by 50%, and decreased urine osmolality by 40%. The same trends of changes in these variables were also observed when L-NAME was added to ZD 7155 or PD 123319, although to a lesser extent.
    ZD 7155

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