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Results for "

graft

" in MedChemExpress (MCE) Product Catalog:

43

Inhibitors & Agonists

12

Biochemical Assay Reagents

4

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7

Inhibitory Antibodies

3

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1

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1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99452

    SNDX-6352

    c-Fms Inflammation/Immunology Cancer
    Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases .
    Axatilimab
  • HY-32340

    KH1060

    VD/VDR Inflammation/Immunology Cancer
    Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases .
    Lexacalcitol
  • HY-16673

    GPR119 Metabolic Disease
    PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders .
    PSN632408
  • HY-P3412

    MAPKAPK2 (MK2) Inflammation/Immunology
    MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
    MMI-0100
  • HY-P990040

    LVGN-6051

    TNF Receptor Cancer
    Exlinkibart (LVGN-6051) targets TNFRSF9 and is an IgG1κ antibody humanized through complementarity-determining region (CDR) grafting technology.
    Exlinkibart
  • HY-Y0850A3

    PVA, MW 64000 (Excipient)

    Biochemical Assay Reagents Cardiovascular Disease
    Polyvinyl alcohol, MW 64000 (PVA, MW 64000) (Excipient) is a water-soluble synthetic polymer with a molecular weight of 64000. Polyvinyl alcohol hydrogel is commonly used as a versatile excipient in biomedical applications including vascular grafting .
    Polyvinyl alcohol, MW 64000 (Excipient)
  • HY-P2799H

    CK-MB, Human heart

    Endogenous Metabolite Cardiovascular Disease
    Creatine kinase-MB (CK-MB), Human heart is a cardiac biomarker that can be used for early-phase risk detection of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) .
    Creatine kinase-MB, Human heart
  • HY-119996A

    Monocarboxylate Transporter Inflammation/Immunology
    AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively . AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response .
    AR-C141990 hydrochloride
  • HY-29347

    Others Cardiovascular Disease
    Ocrylate is a tissue adhesive that contains an 8-carbon alkyl cyanoacrylate in its structure. Ocrylate can be used in research on gastric fundal varices, bone and cartilage grafting, cerebrospinal fluid leakage repair, and skin closure. Additionally, the rapid polymerization property of Ocrylate makes it suitable for inhibiting vascular embolization .
    Ocrylate
  • HY-145995

    Others Others
    CS12192 is a compound improving survival and weight gain. CS12192 has the potential for the research of graft-versus-host disease (GVHD) (extracted from the patent CN112773802A) .
    CS12192
  • HY-115464

    Others Inflammation/Immunology
    NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .
    NC1153
  • HY-15564
    AR 231453
    1 Publications Verification

    GPR119 Metabolic Disease
    AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s .
    AR 231453
  • HY-P99664

    Interleukin Related Inflammation/Immunology
    Inolimomab is an anti-interleukin-2 receptor (IL-2R) α chain monoclonal antibody. Inolimomab improves the survival rate in the early research of treating acute graft-versus-host disease (aGVHD) .
    Inolimomab
  • HY-12514

    Ser/Thr Protease
    NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .
    NK3201
  • HY-P99378

    ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab)

    Apoptosis Inflammation/Immunology
    Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research .
    Neihulizumab
  • HY-13557
    Ascomycin
    Maximum Cited Publications
    6 Publications Verification

    Immunomycin; FR-900520; FK520

    FKBP Parasite Fungal Antibiotic Infection Neurological Disease Inflammation/Immunology
    Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
    Ascomycin
  • HY-P99837

    SPV-T3a

    CD3 Infection
    Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .
    Dafsolimab
  • HY-W440951

    Biochemical Assay Reagents Others
    Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
    Stearic acid-PEG-Mal (MW 3400)
  • HY-124179

    NF-κB Cancer
    IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC50 of 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD) .
    IT-901
  • HY-121508

    NF-κB Inflammation/Immunology Cancer
    (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases .
    (E/Z)-IT-603
  • HY-P99445

    APG101; CAN008

    TNF Receptor Inflammation/Immunology Cancer
    Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD) .
    Asunercept
  • HY-W272217

    n-Octacosane; NSC 5549

    Endogenous Metabolite Bacterial Inflammation/Immunology Cancer
    Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .
    Octacosane
  • HY-125864

    Interleukin Related NF-κB Inflammation/Immunology
    Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .
    Fibrinogen (Bovine)
  • HY-155193

    Others Inflammation/Immunology
    XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model .
    XY-52
  • HY-W156324

    PROTAC Linkers Liposome Others
    Biotin-PEGn-NHS ester is a biotin-labeled PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Biotin-PEGn-NHS ester can interact with free neutral avidin in solution and successfully target malignant glioma cells. Biotin-PEGn-NHS ester can also be grafted onto the amino group of GelMA to prepare biotin-modified functionalized hydrogel, gelatin methacryloyl (Bio-GelMA) .
    Biotin-PEGn-NHS ester
  • HY-152860

    HRX-0215

    p38 MAPK JNK NF-κB MDM-2/p53 Cancer
    Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts .
    Darizmetinib
  • HY-W272217S

    n-Octacosane-d58; NSC 5549-d58

    Bacterial Endogenous Metabolite Cancer
    Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].
    Octacosane-d58
  • HY-164455

    Aurora Kinase JAK STAT Inflammation/Immunology
    AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) .
    AJI-214
  • HY-W272217R

    Endogenous Metabolite Bacterial Inflammation/Immunology Cancer
    Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .
    Octacosane (Standard)
  • HY-125865

    Casein Kinase Endogenous Metabolite Others
    Casein is a phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties, including mechanical properties, water resistance, thermal stability, and barrier properties. Casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials .
    Casein
  • HY-164454

    Aurora Kinase JAK STAT Inflammation/Immunology
    AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values ??of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) .
    AJI-100
  • HY-150298

    CPI-818

    Itk Inflammation/Immunology Cancer
    Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
    Soquelitinib
  • HY-124750

    TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species Cardiovascular Disease Inflammation/Immunology
    NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .
    NecroX-7
  • HY-117649

    Estrogen Receptor/ERR Cancer
    RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen .
    RU-39411
  • HY-158218

    Gelatin Methacryloyl, 30% methacrylation, Red Fluorescent

    Biochemical Assay Reagents Others
    Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 30% methacrylation, Red Fluorescent
  • HY-158217

    Gelatin Methacryloyl, 30% methacrylation, Green Fluorescent

    Biochemical Assay Reagents Others
    Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 30% methacrylation, Green Fluorescent
  • HY-158218B

    Gelatin Methacryloyl, 90% methacrylation, red fluorescent

    Biochemical Assay Reagents Others
    Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 90% methacrylation, red fluorescent
  • HY-158218A

    Gelatin Methacryloyl, 60% methacrylation, red fluorescent

    Biochemical Assay Reagents Others
    Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 60% methacrylation, red fluorescent
  • HY-158217A

    Gelatin Methacryloyl, 60% methacrylation, Green Fluorescent

    Biochemical Assay Reagents Others
    Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 60% methacrylation, Green Fluorescent
  • HY-158217B

    Gelatin Methacryloyl, 90% methacrylation, Green Fluorescent

    Biochemical Assay Reagents Others
    Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
    Application: cell culture, biological 3D printing, tissue engineering, etc.
    GelMA, 90% methacrylation, Green Fluorescent
  • HY-158219

    GelMA, 30% methacrylation, blue fluorescent

    Biochemical Assay Reagents Others
    Gelatin Methacryloyl (GelMA), 30% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity.
    Application direction: cell culture, biological 3D printing, tissue engineering, etc.
    Gelatin Methacryloyl, 30% methacrylation, blue fluorescent
  • HY-158219B

    GelMA, 90% methacrylation, blue fluorescent

    Biochemical Assay Reagents Others
    Gelatin Methacryloyl (GelMA), 90% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 90% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity.
    Application direction: cell culture, biological 3D printing, tissue engineering, etc.
    Gelatin Methacryloyl, 90% methacrylation, blue fluorescent
  • HY-158219A

    GelMA, 60% methacrylation, blue fluorescent

    Biochemical Assay Reagents Others
    Gelatin Methacryloyl (GelMA), 60% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 60% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity.
    Application direction: cell culture, biological 3D printing, tissue engineering, etc.
    Gelatin Methacryloyl, 60% methacrylation, blue fluorescent

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