2. Apoptosis
  3. Apoptosis
  4. Neihulizumab

Neihulizumab  (Synonyms: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab))

Cat. No.: HY-P99378 Purity: 98.10%
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Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research.

For research use only. We do not sell to patients.

Neihulizumab Chemical Structure

Neihulizumab Chemical Structure

CAS No. : 2158362-38-8

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Based on 1 publication(s) in Google Scholar

Neihulizumab Related Antibodies

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Description

Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research[1].

Species

Humanized

In Vitro

Neihulizumab is a monoclonal antibody against P-selectin glycoprotein ligand-1 (PSGL-1). Neihulizumab binds to human PSGL-1, thereby preferentially inducing apoptosis in late stage activated T cells. At sites of inflammation, the endothelium of blood vessels expresses P-selectin, and activated T cells bind to these sites and migrate through the expression of PSGL-1. In that manner, Neihulizumab is thought to target activated T cells and inhibit trafficking to sites of inflamed tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neihulizumab Related Antibodies
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Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Neihulizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Neihulizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neihulizumab2158362-38-8ALTB-168 Anti-PSGL1/CD162 Reference Antibody (neihulizumab)ALTB168ALTB 168Apoptosishumanised monoclonal antibodyCD162PSGL-1SR-aGVHDpsoriasispsoriatic arthritis and ulcerative colitisT-cellsInhibitorinhibitorinhibit

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