2. Apoptosis
  3. Apoptosis
  4. Neihulizumab

Neihulizumab  (Synonyms: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab))

Cat. No.: HY-P99378 Purity: ≥99.0%
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Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research.

For research use only. We do not sell to patients.

CAS No. : 2158362-38-8

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Description

Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized

In Vitro

Neihulizumab is a monoclonal antibody against P-selectin glycoprotein ligand-1 (PSGL-1). Neihulizumab binds to human PSGL-1, thereby preferentially inducing apoptosis in late stage activated T cells. At sites of inflammation, the endothelium of blood vessels expresses P-selectin, and activated T cells bind to these sites and migrate through the expression of PSGL-1. In that manner, Neihulizumab is thought to target activated T cells and inhibit trafficking to sites of inflamed tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neihulizumab Related Antibodies
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT02694770AbGenomics B.V Taiwan Branch
Steroid-refractory aGvHD Subsequent to Allogeneic Hematopoietic Cell Transplantation
July 2016Phase 2
NCT03298022AltruBio Inc.
Ulcerative Colitis
May 4, 2018Phase 2
NCT04144036Sameem M. Abedin, MD|Medical College of Wisconsin
Graft-versus-host Disease
December 14, 2020Phase 1
Molecular Weight

145.72 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Neihulizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized CD162/PSGL-1 Protein, Human (HEK293, His, HY-P77163) can bind Neihulizumab. The EC50 for this effect is 2.298 ng/mL.
Purity & Documentation
References
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Keywords:

Neihulizumab2158362-38-8ALTB-168Anti-PSGL1/CD162 Reference Antibody (neihulizumab)ALTB168ALTB 168Apoptosishumanised monoclonal antibodyCD162PSGL-1SR-aGVHDpsoriasispsoriatic arthritis and ulcerative colitisT-cellsInhibitorinhibitorinhibit

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