gram-negative endotoxin

By Targets:	Antibiotic (3) Bacterial (3) Platelet-activating Factor Receptor (PAFR) (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149179

Polymyxin B 10+ Cited Publications	Bacterial Antibiotic	Infection
Polymyxin B is an antibiotic. Polymyxin B inhibits *Gram-negative* infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research .

HY-A0248

Polymyxin B Sulfate 10+ Cited Publications	Bacterial Antibiotic	Infection
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 Maximum Cited Publications 265 Publications Verification LPS	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. *Lipopolysaccharides, from E. coli* O55:B5 can be used to induce cellular inflammation and establish animal models related to inflammation** .

HY-130581

Lipid X	Bacterial Antibiotic	Infection
Lipid X is a novel monosaccharide precursor of Lipid A (the active moiety of gram-negative endotoxin). Lipid X is protective against endotoxin administered to mice and sheep and against life-threatening gram-negative infections in mice .

HY-19126

CL-184005	Platelet-activating Factor Receptor (PAFR)	Infection Cardiovascular Disease
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC₅₀ of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis .

Cat. No.	Product Name	Type

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 260+ Cited Publications LPS	Carbohydrates
Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. *Lipopolysaccharides, from E. coli* O55:B5 can be used to induce cellular inflammation and establish animal models related to inflammation** .

Lipopolysaccharides, from E. coli O55:B5

260+ Cited Publications

LPS

Carbohydrates

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be used to induce cellular inflammation and establish animal models related to inflammation .

Cat. No.	Product Name	Target	Research Area

HY-A0248

Polymyxin B Sulfate 10+ Cited Publications	Bacterial Antibiotic	Infection
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0248

Polymyxin B Sulfate 10+ Cited Publications	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 260+ Cited Publications LPS	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. *Lipopolysaccharides, from E. coli* O55:B5 can be used to induce cellular inflammation and establish animal models related to inflammation** .

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gram-negative endotoxin

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