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hemolysin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (1) Endogenous Metabolite (2)
By Research Areas:	Cancer (1) Infection (4)

5

Inhibitors & Agonists

2

Peptides

1

Inhibitory Antibodies

3

Natural
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5

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Schisandrone	Others	Cancer
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

Streptolysin O	Endogenous Metabolite	Infection
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

Streptolysin O (≥1000000 units/mg)	Endogenous Metabolite	Infection
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

UM-C162	Bacterial	Infection
UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of i>S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control i>S. aureus infections .

Cat. No.	Product Name	Target	Research Area

Delta-hemolysin Delta-lysin	Peptides	Others
Delta-hemolysin (Delta-lysin), a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin is a model in the study of peptides interacting with membranes. Delta-hemolysin is poorly active against bacteria .

*Delta-hemolysin* TFA** Delta-lysin TFA	Peptides	Others
Delta-hemolysin (Delta-lysin) TFA, a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin TFA may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin TFA is a model in the study of peptides interacting with membranes. Delta-hemolysin TFA is poorly active against bacteria .

Cat. No.	Product Name	Target	Research Area

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

Species:	Staphylococcus aureus (5)
Tag:	His (5) SUMO (1) Myc (2)
Source:	P. pastoris (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	*Alpha-hemolysin* Protein, S. aureus (P.pastoris, His)** hly; hla; Alpha-HL; Alpha-toxin	Staphylococcus aureus	P. pastoris
	The alpha-hemolysin protein binds to eukaryotic cell membranes, triggering the release of low molecular weight molecules and causing osmotic lysis. It inhibits the chemotaxis of host neutrophils toward the diseased area. Alpha-hemolysin Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Alpha-hemolysin protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Alpha-hemolysin Protein, S. aureus (P.pastoris, His) is 293 a.a., with molecular weight of ~35.3 kDa.

	Leukocidin-F subunit/LukF Protein, S. aureus (Myc, His-SUMO) lukF; Leukocidin-F subunit; Gamma-hemolysin; H-gamma-I subunit	Staphylococcus aureus	E. coli
	Leukocidin-F subunit/LukF protein induces cytotoxic changes in polymorphonuclear leukocytes, while gamma-hemolysin, with components H-gamma-I and H-gamma-II identical to F, causes hemolysis in red blood cells. These proteins collectively contribute to pathogenic mechanisms by exerting cytotoxic effects on immune cells and inducing hemolysis in red blood cells. Leukocidin-F subunit/LukF Protein, S. aureus (Myc, His-SUMO) is the recombinant Staphylococcus aureus-derived Leukocidin-F subunit/LukF protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag. The total length of Leukocidin-F subunit/LukF Protein, S. aureus (Myc, His-SUMO) is 298 a.a., with molecular weight of ~54.0 kDa.

	*Gamma-hemolysin* component C Protein, S. aureus (P.pastoris, His)** hlgC; SA2208Gamma-hemolysin component C	Staphylococcus aureus	P. pastoris
	Gamma-hemolysin component C (HLgC) acts as a toxin, forming cell membrane pores with hemolytic and leukotoxic activities. The toxicity of HlgC requires sequential binding and cooperative association with S- and F-class components to form heterooligomeric complexes. Gamma-hemolysin component C Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Gamma-hemolysin component C protein, expressed by P. pastoris , with N-His labeled tag.

	*Gamma-hemolysin* component B Protein, S. aureus (P.pastoris, His)** hlgB; SA2209; Gamma-hemolysin component B; H-gamma-1; H-gamma-I	Staphylococcus aureus	P. pastoris
	Gamma-hemolysin component B (HLgB) acts as a toxin, creating cell membrane pores with hemolytic and leukotoxic activities. Furthermore, HLgB promotes AMFR-mediated inflammation by promoting “Lys-27” linked ubiquitination of TAB3, mediating TAK1-TAB3 complex formation, and activating NF-kappa-B signaling. Gamma-hemolysin component B Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Gamma-hemolysin component B protein, expressed by P. pastoris , with N-His labeled tag. The total length of Gamma-hemolysin component B Protein, S. aureus (P.pastoris, His) is 300 a.a., with molecular weight of ~36.1 kDa.

	*Gamma-hemolysin* component A Protein, S. aureus (Myc, His)** hlgA; hlg2; MW2342; Gamma-hemolysin component A; H-gamma-2; H-gamma-II	Staphylococcus aureus	E. coli
	Gamma-hemolysin component A (HLgA) functions as a toxin and creates cell membrane pores with hemolytic and leukotoxic activities. Its action depends on sequential binding and cooperative association with class S and class F components to form heterooligomeric complexes. Gamma-hemolysin component A Protein, S. aureus (Myc, His) is the recombinant Staphylococcus aureus-derived Gamma-hemolysin component A protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of Gamma-hemolysin component A Protein, S. aureus (Myc, His) is 280 a.a., with molecular weight of ~39.4 kDa.

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