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Results for "

hepatotoxic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (2) Bacterial (1) c-Myc (2) Caspase (1) COX (1) DNA/RNA Synthesis (3) GLUT (1) HIV Protease (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Necroptosis (2) Parasite (1) PI3K (2) Stearoyl-CoA Desaturase (SCD) (1) Topoisomerase (2) URAT1 (1)
By Research Areas:	Cancer (9) Infection (3) Inflammation/Immunology (5) Metabolic Disease (5)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W007318

2-Iodoaniline 2-Iodophenylamine	Others	Others
2-Iodoaniline (2-Iodophenylamine) is an aniline derivative, and has potential hepatotoxic and nephrotoxic activity .

HY-W032848

Tinoridine 1 Publications Verification Y-3642	COX	Inflammation/Immunology
Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .

HY-N6807

Elemicin	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N11433

Celosin L	Others	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-139705

Anticancer agent 12	Others	Cancer
Anticancer agent 12 is unexpectedly devoids of hepatotoxicity while maintaining cytotoxic activity in malignant cells.

HY-N11812

Erucifoline N-oxide	Others	Metabolic Disease
Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .

HY-129384

Rubratoxin B	Others	Cancer
Rubratoxin B is a hepatotoxic mycotoxin that can be found in Penicillium rubrum Stoll. Rubratoxin B shows antitumor activity .

HY-U00337A

Datelliptium chloride hydrochloride	DNA/RNA Synthesis	Cancer
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors .

HY-167863

Piritrexim isethionate BW 301U isethionate; NSC 351521 isethionate	Others	Inflammation/Immunology
Piritrexim isethionate (BW 301U isethionate) is a fat-soluble dihydrofolate reductase inhibitor with activity in the treatment of severe psoriasis. Piritrexim isethionate may be as effective as methotrexate in the treatment of severe psoriasis and may have less hepatotoxicity .

HY-N7905

Myricetin 3'-glucoside	Others	Inflammation/Immunology
Myricetin 3'-glucoside is a glycoside derivative of quercetin. Myricetin 3'-glucoside significantly prevents ethanol-induced hepatotoxicity by reducing hepatic transaminase activity and inflammatory response in HepG2 cells. Myricetin 3'-glucoside has a certain protective effect on alcohol-induced liver injury .

HY-128435

2,4'-Dihydroxybenzophenone-1	Others	Metabolic Disease
2,4'-Dihydroxybenzophenone ((Z)-SU4312) exhibited estrogenic activities. 2,4'-Dihydroxybenzophenone has oral bioactivity that can effectively protect C57BL/6J mice from Acetaminophen (HY-66005, APAP)-induced hepatotoxicity .

HY-W010800

Cholesteryl hemisuccinate	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-W010800A

Cholesterol hemisuccinate Tris salt Cholesterol hydrogen succinate Tris salt; CHS-Tris	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesterol hemisuccinate Tris salt (CHS-Tris) is a with hepatoprotective an anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesterol hemisuccinate Tris salt inhibits tumor growth .

HY-W013627S

trans,trans-2,4-Decadienal-d4	Isotope-Labeled Compounds	Others
trans,trans-2,4-Decadienal-d₄ is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Apoptosis Caspase Parasite	Infection Cancer
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-162829

hURAT1 inhibitor 1	URAT1 GLUT	Metabolic Disease
hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC₅₀s of 0.16 μM and 4.47 μM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics .

HY-N0330

Momordin Ic 3 Publications Verification	Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-N0330R

Momordin Ic (Standard)	Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6807

Elemicin	Infection Asarum sieboldii Miq. Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N0330

Momordin Ic 3 Publications Verification	Kochia scoparia L. Schrad. Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Chenopodiaceae Cancer	Apoptosis Autophagy PI3K c-Myc
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-N11433

Celosin L	Triterpenes Structural Classification Terpenoids Celosia cristata L. Source classification Amaranthaceae Plants	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-N11812

Erucifoline N-oxide	Structural Classification Alkaloids Erinacea anthyllis Link Source classification Pyridine Alkaloids Plants Compositae	Others
Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .

HY-N7905

Myricetin 3'-glucoside	Structural Classification Flavonoids Flavones Source classification Myrtaceae Syzygium malaccense (L.) Merr. et Perry Plants	Others
Myricetin 3'-glucoside is a glycoside derivative of quercetin. Myricetin 3'-glucoside significantly prevents ethanol-induced hepatotoxicity by reducing hepatic transaminase activity and inflammatory response in HepG2 cells. Myricetin 3'-glucoside has a certain protective effect on alcohol-induced liver injury .

HY-N2996

Ganodermanondiol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Derris indica	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-N0330R

Momordin Ic (Standard)	Kochia scoparia L. Schrad. Triterpenes Structural Classification Terpenoids Source classification Plants Chenopodiaceae	Apoptosis Autophagy PI3K c-Myc
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

Cat. No.	Product Name	Chemical Structure

HY-W013627S

trans,trans-2,4-Decadienal-d4
trans,trans-2,4-Decadienal-d₄ is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

trans,trans-2,4-Decadienal-d4

trans,trans-2,4-Decadienal-d₄ is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

Cat. No.	Product Name		Classification

HY-W010800

Cholesteryl hemisuccinate		Cholesterol
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

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hepatotoxic activity

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products