Search Result
Results for "
ionizable cationic lipid
" in MedChemExpress (MCE) Product Catalog:
13
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-160553
-
|
|
Liposome
|
Others
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9322-O16B, an ionizable cationic lipid, is used for LNP generation .
|
-
-
- HY-159709
-
|
|
Liposome
|
Others
|
|
VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
|
-
-
- HY-145739
-
-
-
- HY-160908
-
|
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Liposome
|
Others
|
Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
|
-
-
- HY-171114
-
|
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Liposome
|
Others
|
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DMT7 is an ionizable cationic lipid (pKa = 6.5) that can be used to generate lipid nanoparticles (LNPs) for delivery of mRNA and anticancer drugs in the body .
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-
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- HY-168776
-
|
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Biochemical Assay Reagents
|
Others
|
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(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
|
-
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- HY-159861
-
|
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Liposome
|
Others
|
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Ionizable Lipid 4 is an ionizable cationic lipid and a rearrangement product of the cationic lipid CA-lipid 5 induced by hydrogen peroxide .
|
-
-
- HY-168777
-
|
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Liposome
|
Others
|
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Lipid 7-1 is an ionizable cationic lipid that can be used for the preparation of liposomes .
|
-
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- HY-168775
-
|
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Biochemical Assay Reagents
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Others
|
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Lipid 29d is an unsaturated ionizable cationic lipid that can be utilized in the formation of lipid nanoparticles and the delivery of mRNA .
|
-
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- HY-134780
-
|
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Liposome
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Others
|
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L-369 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles and deliver mRNA .
|
-
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- HY-159735
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|
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Liposome
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Others
|
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Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery .
|
-
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- HY-112757
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DLinDMA
1 Publications Verification
|
Liposome
|
Others
|
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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
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- HY-158796
-
|
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Liposome
|
Others
|
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L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles .
|
-
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- HY-159725
-
|
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Liposome
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Others
|
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BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
|
-
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- HY-168370
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-
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- HY-153372
-
|
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Liposome
|
Others
|
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93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
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- HY-156985
-
|
|
Isotope-Labeled Compounds
Liposome
|
Others
|
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Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
|
-
-
- HY-149156
-
|
|
Liposome
|
Cancer
|
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Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
-
- HY-W590548
-
|
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Liposome
|
Others
|
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ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
|
-
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- HY-W590532
-
|
|
Liposome
|
Others
|
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306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
-
- HY-112251
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D-Lin-MC3-DMA
Maximum Cited Publications
84 Publications Verification
|
Liposome
|
Cancer
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
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- HY-159853
-
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Liposome
|
Inflammation/Immunology
|
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C14-A1 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
|
-
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- HY-W590531
-
-
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- HY-112251A
-
|
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Liposome
|
Cancer
|
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D-Lin-MC3-DMA Excipient, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
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- HY-159854
-
|
|
Liposome
|
Cancer
|
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C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
|
-
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- HY-151511
-
|
|
Liposome
|
Cancer
|
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
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- HY-171113
-
|
|
Liposome
|
Cancer
|
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CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).
|
-
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- HY-159726
-
|
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Liposome
|
Others
|
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C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
|
-
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- HY-172014
-
|
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Liposome
|
Cancer
|
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CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
|
-
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- HY-172016
-
|
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Liposome
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Cancer
|
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CP-LC-0867 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
|
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- HY-172017
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|
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Liposome
|
Cancer
|
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CP-LC-1254 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
|
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- HY-172015
-
|
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Liposome
|
Cancer
|
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CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
|
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- HY-172018
-
|
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Liposome
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Cancer
|
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CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
|
-
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- HY-W598178
-
|
|
Liposome
|
Others
|
|
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
|
-
-
- HY-171019
-
|
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Biochemical Assay Reagents
|
Others
|
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Lipid 119-23 is an ionizable cationic lipid which can be utilized in the formation of lipid nanoparticles and the delivery of mRNA. Lipid 119-23 exhibits an enhanced capability to express functional mCre in several categories of immune cells, spanning the liver, spleen and lung .
|
-
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- HY-112755A
-
|
(R)-DODMA
|
Liposome
|
Metabolic Disease
|
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1,2(R)-Dioleyloxy-3-dimethylamino-propane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA (HY-112755).
|
-
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- HY-156936
-
|
|
Liposome
|
Others
|
|
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
|
-
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- HY-153737
-
|
|
Liposome
|
Others
|
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
|
-
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- HY-157252
-
|
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Liposome
|
Cancer
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
|
-
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- HY-159859
-
|
|
Liposome
|
Others
|
|
IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect .
|
-
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- HY-142654
-
|
|
Liposome
|
Others
|
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
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- HY-159869
-
|
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Liposome
|
Others
|
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G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) .
|
-
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- HY-159860
-
|
|
Liposome
|
Others
|
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IR-117-17 is an ionizable cationic amino lipid, targeting the conducting airways. IR-117-17 could be degraded via esterase cleavage and thus be unlikely to accumulate upon repeated dosing .
|
-
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- HY-W590681
-
|
|
Liposome
|
Others
|
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113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
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- HY-W590679
-
|
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Liposome
|
Others
|
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113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
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- HY-160852
-
|
|
Liposome
|
Inflammation/Immunology
|
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YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
|
-
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- HY-151512
-
-
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- HY-160552
-
|
|
Liposome
|
Others
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
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- HY-112251S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
-
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- HY-145405
-
|
|
Liposome
|
Others
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
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- HY-159700
-
|
|
Liposome
|
Infection
|
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AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
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- HY-130751
-
|
|
Liposome
|
Inflammation/Immunology
|
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DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
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- HY-169478
-
|
|
Liposome
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Cancer
|
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Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies .
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- HY-165604
-
|
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Liposome
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Others
|
C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab’)2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs) .
|
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- HY-169480
-
|
|
Liposome
|
Infection
Cancer
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Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 +CD8 + central and CD3 +CD8 + effector memory T cells and decrease the percentage of CD3 + T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-145739
-
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
Drug Delivery
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-153372
-
|
|
Drug Delivery
|
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
- HY-W590532
-
|
|
Drug Delivery
|
|
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
84 Publications Verification
|
Drug Delivery
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-151511
-
|
|
Drug Delivery
|
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-153737
-
|
|
Drug Delivery
|
|
113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
|
-
- HY-157252
-
|
|
Drug Delivery
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
|
-
- HY-142654
-
|
|
Drug Delivery
|
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
- HY-149156
-
|
|
Drug Delivery
|
|
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
- HY-151512
-
|
|
Drug Delivery
|
|
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
|
-
- HY-145405
-
|
|
Drug Delivery
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-130751
-
|
|
Drug Delivery
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-112251S
-
|
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-160553
-
|
|
|
Cationic Lipids
|
9322-O16B, an ionizable cationic lipid, is used for LNP generation .
|
-
- HY-159709
-
|
|
|
Cationic Lipids
|
|
VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
|
-
- HY-145739
-
-
- HY-160908
-
|
|
|
Cationic Lipids
|
Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
|
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
|
Cationic Lipids
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-158796
-
|
|
|
Cationic Lipids
|
|
L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles .
|
-
- HY-159725
-
|
|
|
Cationic Lipids
|
|
BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
|
-
- HY-153372
-
|
|
|
Cationic Lipids
|
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
- HY-156985
-
|
|
|
Cationic Lipids
|
|
Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
|
-
- HY-149156
-
|
|
|
Cationic Lipids
|
|
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
- HY-W590548
-
|
|
|
Cationic Lipids
|
|
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
|
-
- HY-W590532
-
|
|
|
Cationic Lipids
|
|
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
84 Publications Verification
|
|
Cationic Lipids
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-W590531
-
|
|
|
Cationic Lipids
|
|
80-O16B is an ionizable cationic lipid containing disulfide bonds that can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-112251A
-
-
- HY-151511
-
|
|
|
Cationic Lipids
|
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-159726
-
|
|
|
Cationic Lipids
|
|
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
|
-
- HY-W598178
-
|
|
|
Cationic Lipids
|
|
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
|
-
- HY-156936
-
|
|
|
Cationic Lipids
|
|
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
|
-
- HY-153737
-
|
|
|
Cationic Lipids
|
|
113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
|
-
- HY-157252
-
|
|
|
Cationic Lipids
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
|
-
- HY-142654
-
|
|
|
Cationic Lipids
|
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
- HY-W590681
-
|
|
|
Cationic Lipids
|
|
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-W590679
-
|
|
|
Cationic Lipids
|
|
113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-151512
-
|
|
|
Cationic Lipids
|
|
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
|
-
- HY-160552
-
|
|
|
Cationic Lipids
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
- HY-145405
-
|
|
|
Cationic Lipids
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-159700
-
|
|
|
Cationic Lipids
|
|
AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
|
-
- HY-130751
-
|
|
|
Cationic Lipids
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
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