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Results for "

oxygenation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (1) COX (1) Drug Metabolite (2) Endogenous Metabolite (5) Factor Xa (1) Fungal (1) Glucocorticoid Receptor (1) HIV Protease (1) Isotope-Labeled Compounds (2) JAK (1) Parasite (1) Prostaglandin Receptor (1) Reactive Oxygen Species (3) Sirtuin (2) TRP Channel (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (3) Endocrinology (2) Infection (4) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113351

11β-Hydroxyandrosterone 1 Publications Verification	Endogenous Metabolite	Endocrinology
11β-Hydroxyandrosterone is a 11-oxygenated androgen metabolite of 11β-hydroxyandrostenedione .

HY-N1511

Ganoderic acid D 1 Publications Verification	Sirtuin Apoptosis	Cancer
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-N8712

Umckalin	Others	Others
Umckalin is a oxygenated coumarin from Pelargonium sidoides .

HY-N12804

δ-Cadinol (-)-Torreyol	Others	Others
δ-Cadinol ((-)-Torreyol) is an oxygenated sesquiterpene and can be isolated from Lepechinia salviae (Lindl.) Epling .

HY-N8712R

Umckalin (Standard)	Others	Others
Umckalin (Standard) is the analytical standard of Umckalin. This product is intended for research and analytical applications. Umckalin is a oxygenated coumarin from Pelargonium sidoides .

HY-N10210

Saccharothrixin F	Bacterial	Infection
Saccharothrixin F is a highly oxygenated saccharothrixin, with antibacterial and anti-inflammatory activities .

HY-N1108

Uvedalin	Others	Others
Uvedalin is a conjugated γ-lactone and oxygenated germacranolide that can be isolated from Polymnia uvedalia (L.) .

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Endogenous Metabolite	Neurological Disease
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect .

HY-132849

Nezulcitinib TD-0903	JAK	Infection Inflammation/Immunology
Nezulcitinib (TD-0903) is an inhaled and lung-selective pan-Janus kinase (JAK) inhibitor. Nezulcitinib can be used for the research of COVID-19 associated acute lung injury and impaired oxygenation .

HY-N6957

8-Keto-berberine	Others	Metabolic Disease
8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine .

HY-N1511R

Ganoderic acid D (Standard)	Sirtuin Apoptosis	Cancer
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-W979008

(+)-Isopinocampheol	Others	Others
(+)-Isopinocampheol is an oxygenated monoterpenoid that is important in the chemical ecology of bark beetles .

HY-N2221

Ganoderal A	Others	Metabolic Disease
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-121083

Aerugidiol	Others	Others
Aerugidiol is a bridge-head oxygenated sesquiterpene isolated from the rhizomes of Curcuma aeruginosa .

HY-N1197

Subelliptenone G 1,4,5-Trihydroxyxanthone	Others	Others
Subelliptenone G is a simple oxygenated xanthone that can be isolated from the root bark of Garcinia subelliptica .

HY-N7731

(±)-Lavandulol	Others	Others
(±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .

HY-77839S1

Cortodoxone-d2 11-Deoxycortisol-d₂; cortexolone-d₂; Reichstein's substance S-d₂	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone)[1].

HY-N10428

Ganoapplanoid F	Others	Metabolic Disease
Ganoapplanoid F, a highly oxygenated lanostane triterpenoid from Ganoderma applanatum, inhibits lipid accumulation in adipocytes. Ganoapplanoid F can be used for the research of obesity .

HY-N10934

Ganoderic acid GS-1	HIV Protease	Infection
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM .

HY-13619

Efaproxiral 1 Publications Verification RSR13	Reactive Oxygen Species	Cancer
Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .

HY-13619A

Efaproxiral sodium 1 Publications Verification RSR13 sodium	Reactive Oxygen Species	Cancer
Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

HY-N7731A

(-)-Lavandulol (R)-Lavandulol	Others	Others
(-)-Lavandulol is the isomer of (±)-Lavandulol (HY-N7731). (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .

HY-N1621

1-Deacetylnimbolinin B	Fungal Parasite	Infection
1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties .

HY-N10082

Trigoxyphin A	Others	Cancer
Trigoxyphin A is a oxygenated daphnane-type diterpenoids. Trigoxyphin A exhibites strong cytotoxic activity against HL60 and A549 with IC₅₀s of 0.27 and 7.5 μM, respectively .

HY-N7731R

(±)-Lavandulol (Standard)	Others	Others
(±)-Lavandulol (Standard) is the analytical standard of (±)-Lavandulol. This product is intended for research and analytical applications. (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .

HY-N7117

1,4-Cineole	TRP Channel Endogenous Metabolite	Inflammation/Immunology Cancer
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human TRPA1 .

HY-130239

14(S)-HDHA 14(S)-HDoHE	Drug Metabolite	Neurological Disease
14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-165542

9-cis-Astaxanthin	Others	Others
9-cis-Astaxanthin, an isomer of astaxanthin (3,3-dihydroxy-β,β-carotene-4,4-dione), is part of the xanthophyll family, which consists of oxygenated derivatives of carotenoids.

HY-117358

KW-5805	Others	Inflammation/Immunology
KW-5805 is an anti-ulcer agent that promotes the biosynthesis, storage and secretion of gastric mucus, improves gastric mucosal hemodynamics, and inhibits the decrease in gastric mucosal blood volume and mucosal oxygenation caused by steroid shock .

HY-13619S

Efaproxiral-d6	Isotope-Labeled Compounds Reactive Oxygen Species	Cancer
Efaproxiral-d₆ is the deuterium labeled Efaproxiral. Efaproxiral (RSR13) is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy[1][2].

HY-120893

trans-4,5-Epoxy-(E)-2-decenal	Others	Others
trans-4,5-Epoxy-(E)-2-decenal is an oxygenated α,β-unsaturated aldehyde found in mammalian blood that gives blood its characteristic metallic odor. It is used by predators to locate blood or prey .

HY-130239A

(±)14-HDHA (±)14-HDoHE; 14-hydroxy Docosahexaenoic acid; (±)14-HDoHE	Drug Metabolite	Neurological Disease
(±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .

HY-156613

Frunexian EP-7041	Factor Xa	Cardiovascular Disease
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research .

HY-118736

Ganodermic acid S	Others	Cardiovascular Disease
Ganodermic acid S is an oxygenated triterpenoid, that can be isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae). Ganodermic acid S exerts a concentration dependent inhibition on the response of human gel-filtered platelets (GFP) to U-46619 (HY-108566), a thromboxane (TX) A2 mimetic .

HY-N7117R

1,4-Cineole (Standard)	TRP Channel Endogenous Metabolite	Inflammation/Immunology Cancer
1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole. This product is intended for research and analytical applications. 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene . 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human TRPA1 .

HY-121996

Prostaglandin E2 Ethanolamide PGE2 ethanolamide	Prostaglandin Receptor COX	Inflammation/Immunology
Prostaglandin E2 Ethanolamide (PGE₂-EA), an analog of PGE2, can be formed enzymatically following COX-2 oxygenation of endocannabinoids. Prostaglandin E2 Ethanolamide (PGE₂-EA) could modulate the production of the proinflammatory cytokine TNF-α in human blood and human monocytic cells .

HY-122282

AZ11657312	Others	Cardiovascular Disease
AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased renal medullary perfusion, only in mice treated with angiotensin II. AZ11657312 improves tissue oxygenation by blocking P2X7R, especially in areas of the kidney that are underoxygenated. Administration of AZ11657312 increased sodium excretion up to sixfold while normalizing blood pressure .

HY-106784A

(E)-Ajoene	Others	Neurological Disease
(E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library	2,742 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Oxygen Sensing Compound Library

2,742 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Category	Target	Chemical Structure