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prostaglandin analog

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Prostaglandin Receptor (43) Apoptosis (1) Biochemical Assay Reagents (1) COX (2) DNA/RNA Synthesis (1) Endogenous Metabolite (4) HIV (1) HSV (1) Isotope-Labeled Compounds (1) MMP (2) Nuclear Hormone Receptor 4A/NR4A (1) Potassium Channel (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (16) Endocrinology (30) Infection (1) Inflammation/Immunology (13) Metabolic Disease (14) Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: Prostaglandin Receptor Nucleoside Antimetabolite/Analog PGE synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106916

Unoprostone	Potassium Channel	Cardiovascular Disease Neurological Disease
Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension .

HY-157807

Prostaglandin E2-biotin	Nuclear Hormone Receptor 4A/NR4A	Inflammation/Immunology Cancer
Prostaglandin E2-biotin is a prostaglandin analog. Prostaglandin E2-biotin can be used for research of Nurr1-related disease, such as cancer and autoimmune disease .

HY-118772

17-Phenyl trinor prostaglandin A2	Prostaglandin Receptor Endogenous Metabolite	Endocrinology
17-Phenyl trinor prostaglandin A2 is a synthetic prostaglandin analog .

HY-114867

(15R)-Bimatoprost 15(R)-17-phenyl trinor PGF2α ethyl amide	Others	Endocrinology
(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .

HY-100571

Cloprostenol isopropyl ester	Prostaglandin Receptor	Endocrinology
Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a K_i value of 28 nM .

HY-117717

(Rac)-SC-31391	Prostaglandin Receptor	Others
(Rac)-SC-31391, a prostaglandin analog, is a strong activator of the bladder muscle contractility that enhanced twitch responses elicited by field stimulation in the guinea pig detrusor muscle. (Rac)-SC-31391 contracts human bladder muscle through the activation of PGF_2α receptors .

HY-137133

Prostaglandin E1 alcohol	Others	Inflammation/Immunology Cancer
Prostaglandin E1 alcohol (compound 89) is a prostaglandin analog .

HY-125383

ZK118182 Isopropyl ester	Prostaglandin Receptor	Endocrinology
ZK118182 Isopropyl ester is the isopropyl ester analog of ZK118182, a prostaglandin analog .

HY-118055

15-Deoxy-Δ12,14-prostaglandin A2 15d-PGA2	Others	Inflammation/Immunology
15-Deoxy-Δ12,14-prostaglandin A2 is a synthetic analog of PGA2 .

HY-118681

8-Iso-16-cyclohexyl-tetranor prostaglandin E2	Others	Others
8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is an analog of Prostaglandin E2 (HY-101952) .

HY-116549

Prostaglandin F2α alcohol PGF2α alcohol	Others	Inflammation/Immunology
Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist .

HY-134135

Prostaglandin A1 methyl ester PGA1 methyl ester	Others	Others
Prostaglandin A1 methyl ester (PGA1 methyl ester) is a cyclopentenone analog .

HY-124085

Prostaglandin F1α alcohol	Others	Metabolic Disease
Prostaglandin F1α alcohol is an analog of PGF1α .

HY-122399

Luprostiol	Others	Endocrinology
Luprostiol is a prostaglandin analog. Luprostiol can be used to stimulate endocrine changes in animals .

HY-120467

Bima SA Bimatoprost serinol amide	Prostaglandin Receptor	Endocrinology
Bima SA (Bimatoprost serinol amide) is a Prostaglandin analog and has the potential for the research of glaucoma .

HY-114910

11-Deoxy Prostaglandin E2	Prostaglandin Receptor	Cancer
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC₅₀ of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions .

HY-113481A

17-trans Prostaglandin E3	Others	Inflammation/Immunology Cancer
17-trans Prostaglandin E3 is a prostaglandin analog, and stimulates Nurr1-dependent transcriptional activity. 17-trans Prostaglandin E3 can be used for research of condition associated with Nurr1,such as cancer and autoimmune disease .

HY-158571

17-Phenoxy trinor prostaglandin F2α 17-Phenoxy trinor PGF2α	Others	Metabolic Disease Inflammation/Immunology
17-Phenoxy trinor prostaglandin F_2α is a PGF_2α analog .

HY-120197

17-Phenyl trinor prostaglandin F2α methyl amide	Others	Endocrinology
17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding .

HY-128043

11-Deoxy prostaglandin E1 AY-23578; Doproston B; 11-Deoxy-PGE1	Prostaglandin Receptor	Inflammation/Immunology
11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs .

HY-124241

N-Cyclopropyl bimatoprost	Prostaglandin Receptor	Inflammation/Immunology
N-Cyclopropyl bimatoprost (Formula II), a prostaglandin analog, can be used in the study of epithelial-related conditions .

HY-149588

17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester	Others	Endocrinology
17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester is an analog of PGF2α .

HY-131696

11-deoxy Prostaglandin F1α 11-deoxy PGF1α	Others	Cardiovascular Disease Others
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor .

HY-118599

Prostaglandin F2α ethyl amide	Others	Others
Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .

HY-129920

Prostaglandin E2 methyl ester PGE2 methyl ester	Others	Metabolic Disease
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an lipophilic derivative analog of PGE2 (HY-101952). Prostaglandin E2 methyl ester has more central penetration ability than PGE2 .

HY-137567

Prostaglandin E1 ethanolamide	Prostaglandin Receptor	Cancer
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth .

HY-118648

Prostaglandin F2α methyl ester PGF2α methyl ester; Dinoprost methyl	Others	Others
Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF_2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive .

HY-118624

Fluprostenol methyl ester	Prostaglandin Receptor	Endocrinology
Fluprostenol methyl ester is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals .

HY-131729

16-Phenoxy tetranor Prostaglandin A2	Others	Cardiovascular Disease
16-Phenoxy tetranor Prostaglandin A2 is a metabolite of uprostone and an analog of the antifertility hormone PGF2α .

HY-132277

15-Keto Bimatoprost	Others	Endocrinology
15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive .

HY-134860

Prostaglandin D1 alcohol	Others	Metabolic Disease
Prostaglandin D1 (PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl .

HY-116758

16,16-Dimethyl prostaglandin A1 di-Me-PGA1	DNA/RNA Synthesis HIV HSV	Infection Cancer
16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems .

HY-130522

6β-Prostaglandin I1 6β-PGI1	Others	Others
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID₅₀ (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection) .

HY-158937

15(R)-15-Methyl prostaglandin F2α methyl ester 15(R)-Methyl carboprost; 15(R)-15-Methyl PGF2α methyl ester	Others	Others
15(R)-15-Methyl prostaglandin F2α methyl ester (15(R)-Methyl carboprost) (compound 15R) is a 15-methyl substituted prostaglandin analog, a member of the prostaglandin family, with potential biological activities in a variety of biological systems, but its specific activity mechanism and application details are not described in detail from the existing information.

HY-118414

20-Ethyl prostaglandin E2	Prostaglandin Receptor	Neurological Disease Cancer
20-Ethyl prostaglandin E2 (compound 62) is a PG analog that stimulates Nurr1-dependent transcriptional activity .

HY-B0191S1

Bimatoprost-d4 AGN 192024-d₄	Prostaglandin Receptor	Endocrinology
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-124219

17-Phenoxy trinor prostaglandin F2α ethyl amide 17-Phenoxy trinor PGF2α ethyl amide	Prostaglandin Receptor	Others
17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-128428

Carboprost 15(S)-15-Methyl prostaglandin F2α; 15-Methyl-PGF2α	Prostaglandin Receptor	Endocrinology
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-158595

15(R),19(R)-Hydroxy prostaglandin F2α 15(R),19(R)-Hydroxy PGF2α	Others	Others
15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen .

HY-U00423

CRTH2-IN-1 Ramatroban analog	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC₅₀ of 6 nM in a human DP2 binding assay.

HY-121996

Prostaglandin E2 Ethanolamide PGE2 ethanolamide	Prostaglandin Receptor COX	Inflammation/Immunology
Prostaglandin E2 Ethanolamide (PGE₂-EA), an analog of PGE2, can be formed enzymatically following COX-2 oxygenation of endocannabinoids. Prostaglandin E2 Ethanolamide (PGE₂-EA) could modulate the production of the proinflammatory cytokine TNF-α in human blood and human monocytic cells .

HY-124243

N-Cyclopropyl methyl bimatoprost 17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide	Prostaglandin Receptor	Others
N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-137270

16,16-Dimethyl PGA2 16,16-Dimethyl prostaglandin A2; Di-M-PGA2	Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
16,16-Dimethyl PGA2 is an orally active prostaglandin analog with a prolonged in vivo half-life. 16,16-Dimethyl PGA2 can be used to study hypertension .

HY-129934

Latanoprost ethyl amide Lat-NEt	Prostaglandin Receptor	Endocrinology
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

HY-19518

Latanoprostene bunod NCX116; LBN	Others	Cardiovascular Disease Neurological Disease Cancer
Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .

HY-W746888

17-Phenyl trinor prostaglandin F2α diethyl amide 17-p-PGF2α-NEt2; 17-Phenyl trinor PGF2α diethyl amide	Prostaglandin Receptor	Cardiovascular Disease
17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF_2α analog with hypotensive efficacy .

HY-124200

AL 8810 isopropyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).

HY-B0191S

Bimatoprost-d5 AGN 192024 d₅	Prostaglandin Receptor	Endocrinology
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].

HY-128428R

Carboprost (Standard)	Prostaglandin Receptor	Endocrinology
Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-118190

AL 8810 methyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 methyl ester is a prostaglandin F(2α) analog and a prostaglandin F(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines .

Cat. No.	Product Name	Type

HY-120973

Butaprost free acid

Biochemical Assay Reagents

(R)-Butaprost (free acid). Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost is frequently used pharmacologically to define the expression profile of EP receptors in various human and animal tissues and cells. Gardiner caused serious confusion about the structure of butaprost in 1986 when he reported that the epimer of butaprost showing this selective activity was the C-16 (R)-epimer ( See reference 2 and notes). To increase the binding affinity of (R)-butaprost to prostaglandin receptors, we removed the methyl ester of (R)-butaprost and recreated the native C-1 carboxylic acid. Prostaglandin free acids typically bind their cognate receptors with 10 to 100-fold higher affinity than the corresponding ester derivatives. The pharmacology of (R)-butaprost has not been carefully studied, but it is generally considered to be the less active C-16 epimer. (Note: In the 1986 Gardiner paper in the British Journal of Pharmacology, butaprost appears on page 46 under the designation TR 4979. The structure drawn is incorrect because the authors use and refer to the more active C - The 16 epimer, which is actually 16(S). The structure on page 46 shows the structure as 16(R). It was not until the late 1990s that careful studies in the United States and Japan correctly determined the actual structure of C-16 The type is 16(S) in a compound called butaprost.)

Cat. No.	Product Name	Chemical Structure

HY-B0191S

Bimatoprost-d5
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].

HY-132277S

15-Keto Bimatoprost-d5
15-Keto Bimatoprost-d₅ is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive[1][2].

HY-B0191S1

Bimatoprost-d4
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

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