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Results for "

sarcoplasmic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Calcium Channel (14) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Myosin (1) Na+/K+ ATPase (3) PDGFR (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) Sodium Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (13) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0473

Tetracaine hydrochloride Amethocaine hydrochloride	Calcium Channel	Neurological Disease
Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca ²⁺ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-N2877

Annonacin	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis	Neurological Disease Cancer
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-15718A

Istaroxime hydrochloride 5 Publications Verification PST2744 hydrochloride	Na+/K+ ATPase Calcium Channel	Cardiovascular Disease
Istaroxime hydrochloride is a Na ⁺/K ⁺-ATPase inhibitor (IC₅₀=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

HY-110273

N106	Calcium Channel E1/E2/E3 Enzyme	Cardiovascular Disease
N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research .

HY-134261

8-Br-ADPR 8-Bromoadenosine-5'-O-diphosphoribose	Others	Others
8-Br-ADPR is an analogue and an antagonist of ADP-ribose (ADPR) and regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum .

HY-109992

LY 186126	Phosphodiesterase (PDE)	Cardiovascular Disease
LY 186126 a Indolidan analog, is a phosphodiesterase (PDE) inhibitor. LY 186126 binds to cardiac sarcoplasmic reticulum PDE with high affinity, with a K_d of 5.6 nM .

HY-P6008

Myoregulin MLN peptide	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P6008A

Myoregulin TFA MLN peptide TFA	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) TFA is a member of the regulin family. Myoregulin TFA regulates muscle performance by modulating intracellular calcium handling. Myoregulin TFA interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-121259

Doxorubicinol Adriamycinol; DXR-OL	Endogenous Metabolite	Cardiovascular Disease
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

HY-15293

JTV-519 K201	Calcium Channel	Cardiovascular Disease
JTV-519 (K201) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-15293B

JTV-519 hemifumarate K201 hemifumarate	Calcium Channel	Cardiovascular Disease
JTV-519 hemifumarate (K201 hemifumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-111014

VK-II-36	Calcium Channel	Cardiovascular Disease
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca ²⁺release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations .

HY-15293A

JTV-519 free base K201 free base	Calcium Channel	Cardiovascular Disease
JTV-519 free base (K201 free base) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-D1608

BODIPY FL Thapsigargin	Calcium Channel	Others
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells .

HY-110312

JTV-519 fumarate K201 fumarate	Others	Cardiovascular Disease
JTV-519 fumarate (K201 fumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-P5422

Caloxin 3A1	Calcium Channel	Others
Caloxin 3A1 is a biological active peptide. (This peptide belongs to caloxins, the extracellular plasma membrane (PM) Ca2+ pump inhibitors. Caloxin 3A1 inhibits plasma membrane calcium pumps (PMCAs) but not the sarcoplasmic reticulum Ca2+-pump. This peptide does not inhibit formation of the acylphosphate intermediate from ATP.)

HY-15292

S107 1 Publications Verification	Others	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca ²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca ²⁺ release from sarcoplasmic reticulum . N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research .

HY-124873

SERCA2a activator 1	Calcium Channel	Cardiovascular Disease
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca ²⁺-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure .

HY-16215

Mipsagargin G-202	Drug-Linker Conjugates for ADC	Cancer
Mipsagargin (G-202) is a novel thapsigargin-based targeted proagent consisting of a prostate-specific membrane antigen (PSMA)-specific peptide coupled to an analog of the potent sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump inhibitor Thapsigargin (HY-13433). Mipsagargin is activated by PSMA-mediated cleavage of an inert masking peptide. Mipsagargin has the potential for refractory, advanced or metastatic solid tumours research .

HY-103312

Xestospongin C 3 Publications Verification (-)-Xestospongin C	Calcium Channel Apoptosis	Neurological Disease
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

Cat. No.	Product Name	Type

HY-D1608

BODIPY FL Thapsigargin	Fluorescent Dyes/Probes
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells .

Cat. No.	Product Name	Target	Research Area

HY-P6008

Myoregulin MLN peptide	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P6008A

Myoregulin TFA MLN peptide TFA	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) TFA is a member of the regulin family. Myoregulin TFA regulates muscle performance by modulating intracellular calcium handling. Myoregulin TFA interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

HY-P5422

Caloxin 3A1	Calcium Channel	Others
Caloxin 3A1 is a biological active peptide. (This peptide belongs to caloxins, the extracellular plasma membrane (PM) Ca2+ pump inhibitors. Caloxin 3A1 inhibits plasma membrane calcium pumps (PMCAs) but not the sarcoplasmic reticulum Ca2+-pump. This peptide does not inhibit formation of the acylphosphate intermediate from ATP.)

HY-16215

Mipsagargin G-202	Drug-Linker Conjugates for ADC	Cancer
Mipsagargin (G-202) is a novel thapsigargin-based targeted proagent consisting of a prostate-specific membrane antigen (PSMA)-specific peptide coupled to an analog of the potent sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump inhibitor Thapsigargin (HY-13433). Mipsagargin is activated by PSMA-mediated cleavage of an inert masking peptide. Mipsagargin has the potential for refractory, advanced or metastatic solid tumours research .

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

N-(p-Coumaroyl) Serotonin	Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology	PDGFR
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca ²⁺ release from sarcoplasmic reticulum . N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research .

Xestospongin C 3 Publications Verification (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Structural Classification Animals Source classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

Doxorubicinol Adriamycinol; DXR-OL	Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82186

	SERCA2 ATPase Antibody (YA1931) ATP2A2; ATP2B; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1931), targeting SERCA2 ATPase, with a predicted molecular weight of 115 kDa (observed band size: 115 kDa). SERCA2 ATPase Antibody (YA1931) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, rat background.

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sarcoplasmic

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Antibodies

Natural
Products