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syntenin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EGFR (1) FAK (1) MMP (2) NF-κB (2)
By Research Areas:	Cancer (5)

4

Inhibitors & Agonists

1

Peptides

2

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PDZ1i 113B7	FAK EGFR MMP	Cancer
PDZ1i is a potent, BBB-penetrated and specific *MDA-9/Syntenin* inhibitor. PDZ1i inhibits crucial GBM (glioblastoma multiforme) signaling involving FAK and EGFRvIII. PDZ1i reduces MMP secretion. PDZ1i can improve survival of brain tumor-bearing mice and reduce tumor invasion .

SPDZi1	NF-κB	Cancer
SPDZi1 is a potent and selective *syntenin* inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a K_d of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin .

IVMT-Rx-3	NF-κB MMP	Cancer
IVMT-Rx-3 is a inhibitor of SDCBP targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin. IVMT-Rx-3 blocks MDA-9/Syntenin interaction with Src, reduces NF-κB activation, and inhibits MMP-2/MMP-9 expression. IVMT-Rx-3 inhibits Melanoma Metastasis ^[1]

SYNTi	Others	Cancer
SYNTi is a PDZ domain inhibitor targeting the *syndecan/syntenin* protein-protein Interaction. SYNTi exhibits an IC₅₀ value of 400 nM and ligand efficiency (LE) value of 0.24. SYNTi can be used for breast cancer research .

Cat. No.	Product Name	Target	Research Area

KSL 128114	Peptides	Cancer
KSL 128114, a peptide inhibitor of *syntenin, binds the PDZ1 domain of syntenin* with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and displays a global PDZ domain selectivity for syntenin .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	Syntenin-1 Protein, Human (C-His) syntenin-1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP; MDA9; SYCL;	Human	E. coli
	Syntenin-1 is a multifunctional adapter protein that coordinates multiple cellular processes, including transmembrane protein trafficking, neural and immune regulation, exosome biogenesis, and tumorigenesis. It actively regulates TGFB1 signaling and enhances SMAD2/3 activation, TGFB1-induced epithelial-mesenchymal transition (EMT), and cell migration. Syntenin-1 Protein, Human (C-His) is the recombinant human-derived Syntenin-1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Syntenin-1 Protein, Human (C-His) is 297 a.a., with molecular weight of ~ 32.0 kDa.

	Syntenin-1 Protein, Human (N-His) syntenin-1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP; MDA9; SYCL;	Human	E. coli
	Syntenin-1 protein is known to mediate Syndecan signaling and has a PDZ domain that binds transmembrane proteins. It affects cytoskeletal membrane organization, cell adhesion, protein trafficking, and transcription factor activation. Syntenin-1 Protein, Human (N-His) is the recombinant human-derived Syntenin-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Syntenin-1 Protein, Human (N-His) is 298 a.a., with molecular weight of ~32 kDa.

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	Syntenin 1 Antibody (YA1051) SDCBP; MDA9; SYCL; syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human
	Syntenin 1 Antibody (YA1051) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1051), targeting Syntenin 1, with a predicted molecular weight of 32 kDa (observed band size: 32 kDa). Syntenin 1 Antibody (YA1051) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.

	Syntenin 1 Antibody (YA1050) SDCBP; MDA9; SYCL; syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1	WB	Human
	Syntenin 1 Antibody (YA1050) is a biotin-conjugated non-conjugated IgG2b antibody, targeting Syntenin 1, with a predicted molecular weight of 32 kDa (observed band size: 32 kDa). Syntenin 1 Antibody (YA1050) can be used for WB experiment in human background.

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