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Results for "

thrombotic

" in MedChemExpress (MCE) Product Catalog:

48

Inhibitors & Agonists

2

Biochemical Assay Reagents

2

Peptides

1

Inhibitory Antibodies

12

Natural
Products

7

Isotope-Labeled Compounds

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137431A
    (R)-Asundexian

    (R)-BAY-2433334

    		 TNF Receptor Drug Isomer Cardiovascular Disease
    (R)-Asundexian ((R)-BAY-2433334) is the enantiomer of Asundexian (HY-137431). (R)-Asundexian can be used in studies of cardiovascular disease (especially thrombotic or thromboembolic disease), edema, and ophthalmic disease .
    (R)-Asundexian
  • HY-P99227
    Caplacizumab

    ALX-0681; ALX-0081

    		 Integrin Inflammation/Immunology Cancer
    Caplacizumab (ALX-0681) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab can be used for the research of thrombotic thrombocytopenic purpura (TTP) .
    Caplacizumab
  • HY-N0728
    α-Linolenic acid
    5 Publications Verification

    		 PI3K Akt Cardiovascular Disease Cancer
    α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
    α-Linolenic acid
  • HY-19229
    TAK-029

    		Integrin Cardiovascular Disease
    TAK-029 is a potent GP IIb/IIIa antagonist. TAK-029 has potent antithrombotic effects with bleeding time (BT) prolongation in arterial thrombosis models. TAK-029 can be used for the research of various arterial thrombotic diseases .
    TAK-029
  • HY-19660
    Inogatran

    H-314-27

    		 Thrombin Cardiovascular Disease
    Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.
    Inogatran
  • HY-W091734
    Methyl 4-iodo-L-phenylalaninate hydrochloride

    		Amino Acid Derivatives Cardiovascular Disease Neurological Disease
    Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .
    Methyl 4-iodo-L-phenylalaninate hydrochloride
  • HY-106932
    L-734217

    		Integrin Cardiovascular Disease
    L-734217 is an orally active and potent fibrinogen receptor antagonist and an antithrombotic agent. L-734217 is excreted largely by the renal route and partly into the bile in dogs. L-734217 is promising for research of thrombotic disorders .
    L-734217
  • HY-10315
    Elarofiban

    RWJ-53308

    		 Integrin Cardiovascular Disease
    Elarofiban (RWJ-53308) is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban has the potential for platelet mediated thrombotic disorders research .
    Elarofiban
  • HY-129786
    LG 82-4-00

    		Prostaglandin Receptor Cardiovascular Disease
    LG 82-4-00 is a thromboxane (TX) synthase inhibitor with an IC50 value of 1.1 μM. LG 82-4-00 can inhibit collagen-induced TXB2 formation and platelet aggregation in plasma. LG 82-4-00 can be used in studies related to thrombotic diseases .
    LG 82-4-00
  • HY-10315A
    Elarofiban diTFA

    		Integrin Cardiovascular Disease
    Elarofiban diTFA is the salt form of Elarofiban (HY-10315) with two TFA. Elarofiban diTFA is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban diTFA has the potential for platelet mediated thrombotic disorders research .
    Elarofiban diTFA
  • HY-N0728A
    α-Linolenic acid sodium

    ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3

    		 Akt PI3K Cardiovascular Disease Cancer
    α-Linolenic acid sodium, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
    α-Linolenic acid sodium
  • HY-143313
    Protease-Activated Receptor-1 antagonist 1

    		Protease Activated Receptor (PAR) Cardiovascular Disease
    Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor-1 (PAR-1) antagonist with the IC50 of 3 nM by FLIPR technology. Protease-Activated Receptor-1 antagonist 1 can be used for the research of thrombotic cardiovascular, myocardial infarction, and peripheral arterial disease .
    Protease-Activated Receptor-1 antagonist 1
  • HY-N0728R
    α-Linolenic acid (Standard)

    		PI3K Akt Cardiovascular Disease Cancer
    α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
    α-Linolenic acid (Standard)
  • HY-N0570
    Hydroxytyrosol
    5 Publications Verification

    DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol

    		 Endogenous Metabolite Bacterial Fungal Infection Inflammation/Immunology Cancer
    Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects .
    Hydroxytyrosol
  • HY-113439
    12-HETE
    1 Publications Verification

    		 Apoptosis Cardiovascular Disease Inflammation/Immunology
    12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
    12-HETE
  • HY-147079A
    Egaptivon pegol sodium

    ARC 1779 sodium

    		 Integrin Cardiovascular Disease
    Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.
    Egaptivon pegol sodium
  • HY-163685
    Bisobrin

    EN-1661

    		 Others Others
    Bisobrin (EN-1661) is a synthetic compound that may affect the thrombolytic system to promote thrombolysis and thereby play a role in inhibiting thrombotic diseases .
    Bisobrin
  • HY-147079
    Egaptivon pegol

    ARC 1779

    		 Integrin Cardiovascular Disease
    Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
    Egaptivon pegol
  • HY-D1005H
    Poloxamer 188 (F68)

    PEG-PPG-PEG, 8400(Average Mn)

    		 Fluorescent Dye Biochemical Assay Reagents Others
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .
    Poloxamer 188 (F68)
  • HY-N8903
    Mumefural

    		Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor Cardiovascular Disease Neurological Disease
    Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .
    Mumefural
  • HY-N4271
    Protogracillin

    		Others Cardiovascular Disease
    Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW). Steroidal saponins from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action .
    Protogracillin
  • HY-10725
    Tanogitran

    		Factor Xa Cardiovascular Disease
    Tanogitran is a dual inhibitor targeting Factor Xa and thrombin (thrombin), with Ki values of 26 and 2.7 nM, respectively. Tanogitran exhibits anticoagulant activity and can be used for research in thrombotic diseases .
    Tanogitran
  • HY-B1237A
    Suloctidil hydrochloride

    		Na+/K+ ATPase Cardiovascular Disease
    Suloctidil hydrochloride hydrochloride is an active agent against on Na+/K+ ATPase activity and on membrane fluidity in rat brain synaptosomes. Suloctidil hydrochloride is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders.
    Suloctidil hydrochloride
  • HY-W011690
    L-Homocystine

    		Endogenous Metabolite Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
    L-Homocystine
  • HY-B1237
    Suloctidil

    		Na+/K+ ATPase Cardiovascular Disease
    Suloctidil is a new drug that is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders Target： Effect of suloctidil on Na+/K+ ATPase activity and on membrane fluidity in rat brain synaptosomes.
    Suloctidil
  • HY-113439S
    12-HETE-d8

    		Apoptosis Cardiovascular Disease Inflammation/Immunology
    12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
    12-HETE-d8
  • HY-N0570R
    Hydroxytyrosol (Standard)

    		Endogenous Metabolite Bacterial Fungal Infection Inflammation/Immunology Cancer
    Hydroxytyrosol (Standard) is the analytical standard of Hydroxytyrosol. This product is intended for research and analytical applications. Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects .
    Hydroxytyrosol (Standard)
  • HY-P2813
    Hirudin

    		Thrombin Apoptosis Cardiovascular Disease Cancer
    Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .
    Hirudin
  • HY-D1005A
    Poloxamer 188

    PEG-PPG-PEG, 8800 (Average Mn)

    		 Biochemical Assay Reagents Inflammation/Immunology
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .
    Poloxamer 188
  • HY-167858
    LK-732

    		Thrombin Cardiovascular Disease
    LK-732 is a thrombin inhibitor with anti-thrombotic activity.LK-732 has a dose-dependent inhibition of hypercoagulability in the model, with an IC50 of 1.3 mg/kg. LK-732 can be used in cardiovascular and cerebrovascular research .
    LK-732
  • HY-N0570S1
    Hydroxytyrosol-d5

    DOPET-d5; 3,4-Dihydroxyphenethyl alcohol-d5; 3-Hydroxytyrosol-d5

    		 Endogenous Metabolite Bacterial Fungal Infection Inflammation/Immunology Cancer
    Hydroxytyrosol-d5 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
    Hydroxytyrosol-d5
  • HY-N0570S
    Hydroxytyrosol-d4

    DOPET-d4; 3,4-Dihydroxyphenethyl alcohol-d4; 3-Hydroxytyrosol-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Fungal Infection Inflammation/Immunology Cancer
    Hydroxytyrosol-d4 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
    Hydroxytyrosol-d4
  • HY-W011690S
    L-Homocystine-d8

    		Endogenous Metabolite Metabolic Disease
    L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
    L-Homocystine-d8
  • HY-15468
    IOX2
    Maximum Cited Publications
    13 Publications Verification

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases .
    IOX2
  • HY-15468A
    IOX2 sodium

    		HIF/HIF Prolyl-Hydroxylase Cardiovascular Disease Cancer
    IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases .
    IOX2 sodium
  • HY-10594
    Letaxaban

    TAK-442

    		 Factor Xa Cardiovascular Disease Inflammation/Immunology
    Letaxaban (TAK-442) is an orally active and selective direct FXa inhibitor. Letaxaban is a drug with dual anticoagulant and anti-inflammatory activity that works by directly inhibiting FXa and by intervening in the PAR1 signaling pathway. Letaxaban can be used in the study of thrombotic diseases, cardiovascular diseases and inflammation-related diseases .
    Letaxaban
  • HY-N0496
    Ruscogenin
    3 Publications Verification

    		 NOD-like Receptor (NLR) Cardiovascular Disease
    Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .
    Ruscogenin
  • HY-N0367
    Trans-Anethole
    2 Publications Verification

    (E)​-Anethole

    		 Endogenous Metabolite Cardiovascular Disease Metabolic Disease Endocrinology Cancer
    Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .
    Trans-Anethole
  • HY-N0496R
    Ruscogenin (Standard)

    		NOD-like Receptor (NLR) Cardiovascular Disease
    Ruscogenin (Standard) is the analytical standard of Ruscogenin. This product is intended for research and analytical applications. Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .
    Ruscogenin (Standard)
  • HY-143315
    Protease-Activated Receptor-1 antagonist 3

    		Protease Activated Receptor (PAR) Cardiovascular Disease
    Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC50 value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K + channel with an IC50 value of 9 µM .
    Protease-Activated Receptor-1 antagonist 3
  • HY-N0728S2
    α-Linolenic acid-d14

    		PI3K Akt Cardiovascular Disease Cancer
    α-Linolenic acid-d14 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
    α-Linolenic acid-d14
  • HY-N0728S
    α-Linolenic acid-d5

    		PI3K Akt Cardiovascular Disease Cancer
    α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
    α-Linolenic acid-d5
  • HY-N0728S3
    α-Linolenic acid-13C18

    		Isotope-Labeled Compounds PI3K Akt Cardiovascular Disease Cancer
    α-Linolenic acid- 13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
    α-Linolenic acid-13C18
  • HY-124858
    SC99

    		STAT JAK Apoptosis Cardiovascular Disease Cancer
    SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities .
    SC99
  • HY-W004283R
    Pentadecanoic acid (Standard)

    		Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis Metabolic Disease Cancer
    α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
    Pentadecanoic acid (Standard)
  • HY-132828
    Odatroltide

    LT3001; DHDMIQK(KAP)

    		 P-selectin Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .
    Odatroltide
  • HY-120265
    MIPS-9922

    		PI3K Cardiovascular Disease
    MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities .
    MIPS-9922
  • HY-N0367R
    Trans-Anethole (Standard)

    		Endogenous Metabolite Cardiovascular Disease Metabolic Disease Endocrinology Cancer
    Trans-Anethole (Standard) is the analytical standard of Trans-Anethole. This product is intended for research and analytical applications. Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .
    Trans-Anethole (Standard)

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