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wasabi

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By Targets:	Bacterial (1) Keap1-Nrf2 (1) TGF-β Receptor (1) TRP Channel (2)
By Research Areas:	Cancer (1) Infection (1) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Wasabi Receptor Toxin TFA WaTx TFA	TRP Channel	Neurological Disease
Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

Hesperin	Keap1-Nrf2	Cancer
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.

Isosaponarin	TGF-β Receptor	Others
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production .

(6-Isothiocyanatohexyl)(methyl)sulfane Lesquerellin; 6-Methylthiohexyl isothiocyanate	Bacterial	Infection
(6-Isothiocyanatohexyl)(methyl)sulfane (Lesquerellin; 6-Methylthiohexyl isothiocyanate) is an isothiocyanate found in wasabi (W. japonica) and has various biological activities. (6-Isothiocyanatohexyl)(methyl)sulfane is active against the bacterium Bacillus subtilis and the fungus T. mentagrophytes (MIC=25 μg/mL). (6-Isothiocyanatohexyl)(methyl)sulfane also has anthelmintic activity against blue mussel (M. edulis). (6-Isothiocyanatohexyl)(methyl)sulfane has antifouling activity when applied to polyvinyl chloride (PVC) panels at a concentration of 50 μmol/cm2 in a conventional immersion test.

Wasabi Receptor Toxin WaTx	TRP Channel	Neurological Disease
Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

Galangal acetate	Others	Others
Galangal acetate is a wasabi-like spicy compound .

Cat. No.	Product Name	Target	Research Area

Wasabi Receptor Toxin TFA WaTx TFA	TRP Channel	Neurological Disease
Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

Wasabi Receptor Toxin WaTx	TRP Channel	Neurological Disease
Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

Species:	Human (2)
Tag:	His (1) MBP (1) Flag (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	TRPA1 Protein, Human (HEK293, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, FLAG) is the recombinant human-derived TRPA1, expressed by HEK293 , with C-Flag labeled tag. ,

	TRPA1 Protein, Human (HEK293, His, MBP, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag. The total length of TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is 1118 a.a. .

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