2. Cell Cycle/DNA Damage
  3. CDK
  4. Senexin A hydrochloride

Senexin A hydrochloride is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters.

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Senexin A hydrochloride Chemical Structure

Senexin A hydrochloride Chemical Structure

CAS No. : 1780390-76-2

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Senexin A hydrochloride Related Antibodies

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Description

Senexin A hydrochloride is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters[1][2].

IC50 & Target[2]

CDK8

280 nM (IC50)

CDK8

0.83 μM (Kd)

CDK19

0.31 μM (Kd)

In Vitro

Senexin A hydrochloride inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 μM and 0.31 μM, respectively[1].
Senexin A hydrochloride inhibits β-catenin-dependent transcription in HCT116 colon cancer cells[1].
In HT1080 cells, Senexin A hydrochloride strongly inhibits the induction of the transcription factor EGR1 upon serum starvation[1].
Senexin A hydrochloride also reduces the expression of many secreted tumor-promoting factors in doxorubicin-treated wild-type HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Senexin A hydrochloride Related Antibodies
In Vivo

Senexin A hydrochloride (5 times daily) completely reverses the tumor-promoting effects of chemotherapy. Senexin A hydrochloride had no significant toxicity to body weight, organ weights, or blood cell counts in C57BL/6 mice during treatment. Senexin A hydrochloride treatment significantly improves A549/MEF tumor response to Doxorubicin (HY-15142A)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

310.78

Formula

C17H15ClN4
CAS No.
SMILES

N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Senexin A hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Senexin A1780390-76-2CDKCyclin dependent kinasetranscription downstreamCDK8CDK19Inhibitorinhibitorinhibit

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