2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. SENP1-IN-1

SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement.

For research use only. We do not sell to patients.

SENP1-IN-1 Chemical Structure

SENP1-IN-1 Chemical Structure

CAS No. : 2416910-69-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 638 In-stock
Solution
10 mM * 1 mL in DMSO USD 638 In-stock
Solid
5 mg USD 580 In-stock
10 mg USD 1150 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 4800 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SENP1-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement[1].

IC50 & Target

SENP1[1]
In Vitro

SENP1-IN-1 may improve the sensitivity of tumor cells to irradiation[1].
SENP1-IN-1 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SENP1-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Hela cells
Concentration: 0.7 μM, 2.2 μM, 6.6 μM, 20 μM
Incubation Time: 72 hours
Result: IC50>20 μM
Molecular Weight

570.85

Formula

C35H58N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(NCC(N(CCO)C)=O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (175.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7518 mL 8.7589 mL 17.5177 mL
5 mM 0.3504 mL 1.7518 mL 3.5035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7518 mL 8.7589 mL 17.5177 mL 43.7943 mL
5 mM 0.3504 mL 1.7518 mL 3.5035 mL 8.7589 mL
10 mM 0.1752 mL 0.8759 mL 1.7518 mL 4.3794 mL
15 mM 0.1168 mL 0.5839 mL 1.1678 mL 2.9196 mL
20 mM 0.0876 mL 0.4379 mL 0.8759 mL 2.1897 mL
25 mM 0.0701 mL 0.3504 mL 0.7007 mL 1.7518 mL
30 mM 0.0584 mL 0.2920 mL 0.5839 mL 1.4598 mL
40 mM 0.0438 mL 0.2190 mL 0.4379 mL 1.0949 mL
50 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8759 mL
60 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7299 mL
80 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5474 mL
100 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4379 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SENP1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SENP1-IN-12416910-69-3E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasespecificdeSUMOylationproteaseSENP1tumorradiosensitivityenhancementradiosensitizersmallubiquitin-like modifierSUMOInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SENP1-IN-1
Cat. No.:
HY-134594
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.