2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SG-094

SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.

For research use only. We do not sell to patients.

SG-094 Chemical Structure

SG-094 Chemical Structure

CAS No. : 2922283-37-0

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Customer Review

Based on 1 publication(s) in Google Scholar

SG-094 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1].

IC50 & Target

TPC2[1]
In Vitro

SG-094 (72 hours) shows antiproliferative effects against RIL175 cells, with an IC50 of 3.7 μM[1].
SG-094 (10 μM) blocks PI(3,5)P2-elicited TPC2 currents on isolated endolysosomes from HEK293 cells expressing TPC2-EGFP[1].
SG-094 (10 μM; pretreated for 1 h) significantly reduces VEGF-induced phosphorylation of eNOS, JNK, MAPK, and AKT without decreasing their total protein levels in HUVECs[1].
SG-094 (1-5 μM; pretreated for 1 h) increases OCR/ECAR ratios of RIL175 WT cells after glucose starvation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SG-094 Related Antibodies

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 10 μM
Incubation Time: Pretreated for 1 h before stimulation with VEGF-A165 for 15 min
Result: Significantly reduced VEGF-induced phosphorylation of several downstream targets, such as eNOS, JNK, MAPK, and AKT.
In Vivo

SG-094 (90 nmol/kg; every 2-3 days over a 10-day timescale) inhibits hepatocellular carcinoma (HCC) tumor growth in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6-Tyr mice were injected with RIL175 WT cells[1]
Dosage: 90 nmol/kg
Administration: Every 2-3 days over a 10-day timescale
Result: Inhibited tumor growth.
Molecular Weight

451.56

Formula

C30H29NO3
CAS No.
Appearance

Oil

Color

Light brown to brown

SMILES

COC1=C(OC2=CC=CC=C2)C=C(C(CC3=CC=C(OC4=CC=CC=C4)C=C3)N(C)CC5)C5=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (276.82 mM; Need ultrasonic)

DMSO : 100 mg/mL (221.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2145 mL 11.0727 mL 22.1455 mL
5 mM 0.4429 mL 2.2145 mL 4.4291 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.2145 mL 11.0727 mL 22.1455 mL 55.3636 mL
5 mM 0.4429 mL 2.2145 mL 4.4291 mL 11.0727 mL
10 mM 0.2215 mL 1.1073 mL 2.2145 mL 5.5364 mL
15 mM 0.1476 mL 0.7382 mL 1.4764 mL 3.6909 mL
20 mM 0.1107 mL 0.5536 mL 1.1073 mL 2.7682 mL
25 mM 0.0886 mL 0.4429 mL 0.8858 mL 2.2145 mL
30 mM 0.0738 mL 0.3691 mL 0.7382 mL 1.8455 mL
40 mM 0.0554 mL 0.2768 mL 0.5536 mL 1.3841 mL
50 mM 0.0443 mL 0.2215 mL 0.4429 mL 1.1073 mL
60 mM 0.0369 mL 0.1845 mL 0.3691 mL 0.9227 mL
80 mM 0.0277 mL 0.1384 mL 0.2768 mL 0.6920 mL
100 mM 0.0221 mL 0.1107 mL 0.2215 mL 0.5536 mL
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SG-094 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SG-0942922283-37-0SG094SG 094Calcium ChannelCa2+ channelsCa channelsTPC2antiproliferativecancerInhibitorinhibitorinhibit

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