2. Epigenetics Anti-infection
  3. Histone Methyltransferase Fungal Antibiotic Parasite
  4. Sinefungin

Sinefungin  (Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP)

Cat. No.: HY-101938 Purity: 99.91%
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Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation.

For research use only. We do not sell to patients.

Sinefungin Chemical Structure

Sinefungin Chemical Structure

CAS No. : 58944-73-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 319 In-stock
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10 mM * 1 mL in Water USD 319 In-stock
Solid
1 mg USD 270 In-stock
5 mg USD 380 In-stock
10 mg USD 600 In-stock
25 mg USD 1280 In-stock
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100 mg USD 3950 In-stock
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Based on 2 publication(s) in Google Scholar

Sinefungin Related Antibodies

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  • Biological Activity

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  • Customer Review

Description

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

In Vitro

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sinefungin Related Antibodies

Western Blot Analysis[2]

Cell Line: Renal epithelial cells.
Concentration: 0.5 or 1.0 μg/mL.
Incubation Time: Pretreatment 60 minutes before TGF-β1 (10 ng/mL).
Result: Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
In Vivo

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8 weeks of age)[2].
Dosage: 10 mg/kg
Administration: Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).
Result: Inhibited α-SMA protein expression.
Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
Molecular Weight

381.39

Formula

C15H23N7O5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (262.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6220 mL 13.1099 mL 26.2199 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

COA (247 KB) HNMR (246 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6220 mL 13.1099 mL 26.2199 mL 65.5497 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL 13.1099 mL
10 mM 0.2622 mL 1.3110 mL 2.6220 mL 6.5550 mL
15 mM 0.1748 mL 0.8740 mL 1.7480 mL 4.3700 mL
20 mM 0.1311 mL 0.6555 mL 1.3110 mL 3.2775 mL
25 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6220 mL
30 mM 0.0874 mL 0.4370 mL 0.8740 mL 2.1850 mL
40 mM 0.0655 mL 0.3277 mL 0.6555 mL 1.6387 mL
50 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3110 mL
60 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0925 mL
80 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8194 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.6555 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sinefungin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sinefungin58944-73-3Adenosyl-Ornithine A-9145 Antibiotic 32232RPA9145A 9145A-9145Histone MethyltransferaseFungalAntibioticParasiteUUPα-SMAFSP-1collagen 1collagen 3H3K4Inhibitorinhibitorinhibit

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