2. Immunology/Inflammation Cell Cycle/DNA Damage
  3. NOD-like Receptor (NLR) NEKs
  4. SLC3037

SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases.

For research use only. We do not sell to patients.

SLC3037 Chemical Structure

SLC3037 Chemical Structure

Size Price Stock Quantity
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 1000 In-stock
50 mg USD 1600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SLC3037 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SLC3037

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

View All NEKs Isoform Specific Products:

View All Isoforms
NEK1 NEK2 NEK6 NEK7

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases[1].

IC50 & Target

NLRP3

 

NEK7

 

In Vitro

SLC3037 (1-10 μM, 5 h) inhibits the IL-1β induced by LPS and MSU dose-dependently in BMDMs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLC3037 Related Antibodies
Molecular Weight

529.70

Formula

C29H35N7OS
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN(CCNC(C1=CC(C2=CSC3=C2N=C(N=C3)NC4=CC=C(C=C4)N5CCN(CC5)CC)=CC=C1)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (377.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8879 mL 9.4393 mL 18.8786 mL
5 mM 0.3776 mL 1.8879 mL 3.7757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8879 mL 9.4393 mL 18.8786 mL 47.1965 mL
5 mM 0.3776 mL 1.8879 mL 3.7757 mL 9.4393 mL
10 mM 0.1888 mL 0.9439 mL 1.8879 mL 4.7197 mL
15 mM 0.1259 mL 0.6293 mL 1.2586 mL 3.1464 mL
20 mM 0.0944 mL 0.4720 mL 0.9439 mL 2.3598 mL
25 mM 0.0755 mL 0.3776 mL 0.7551 mL 1.8879 mL
30 mM 0.0629 mL 0.3146 mL 0.6293 mL 1.5732 mL
40 mM 0.0472 mL 0.2360 mL 0.4720 mL 1.1799 mL
50 mM 0.0378 mL 0.1888 mL 0.3776 mL 0.9439 mL
60 mM 0.0315 mL 0.1573 mL 0.3146 mL 0.7866 mL
80 mM 0.0236 mL 0.1180 mL 0.2360 mL 0.5900 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4720 mL
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SLC3037 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC3037SLC 3037SLC-3037NOD-like Receptor (NLR)NEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesNLRP3NEK7inflammasomegoutcardiovascular diseasesmetabolic syndromeneurodegenerative diseaseInhibitorinhibitorinhibit

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