2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. SMARCA-BD ligand 1 for PROTAC dihydrochloride

SMARCA-BD ligand 1 for PROTAC dihydrochloride 

Cat. No.: HY-44012A Purity: 98.56%
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SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

For research use only. We do not sell to patients.

SMARCA-BD ligand 1 for PROTAC dihydrochloride Chemical Structure

SMARCA-BD ligand 1 for PROTAC dihydrochloride Chemical Structure

CAS No. : 2369053-68-7

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Based on 1 publication(s) in Google Scholar

Other Forms of SMARCA-BD ligand 1 for PROTAC dihydrochloride:

SMARCA-BD ligand 1 for PROTAC dihydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SMARCA-BD ligand 1 for PROTAC dihydrochloride

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Description

SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

IC50 & Target

SMARCA2[1]
Molecular Weight

344.24

Formula

C14H19Cl2N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 2.7 mg/mL (7.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9050 mL 14.5248 mL 29.0495 mL
5 mM 0.5810 mL 2.9050 mL 5.8099 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9050 mL 14.5248 mL 29.0495 mL 72.6238 mL
5 mM 0.5810 mL 2.9050 mL 5.8099 mL 14.5248 mL
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SMARCA-BD ligand 1 for PROTAC dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA-BD ligand 1 for PROTAC2369053-68-7Ligands for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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SMARCA-BD ligand 1 for PROTAC dihydrochloride
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