2. Immunology/Inflammation
  3. STING
  4. SN-001

SN-001 is a STING inhibitor with an IC50 of 3.82 μM.

For research use only. We do not sell to patients.

SN-001 Chemical Structure

SN-001 Chemical Structure

CAS No. : 727699-84-5

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Based on 1 publication(s) in Google Scholar

SN-001 Related Antibodies

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Description

SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1].

IC50 & Target

IC50: 3.82 μM (STING)[1]
In Vitro

SN-001 targets the cyclic dinucleotide binding pocket of human STING[1].
SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells[1].
SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SN-001 Related Antibodies

Western Blot Analysis[1]

Cell Line: L929 cells
Concentration: 10 μM
Incubation Time: 3 h
Result: Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65.
Molecular Weight

476.52

Formula

C26H21FN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(OC)C(NS(=O)(C4=CC=C(F)C=C4)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (524.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0985 mL 10.4927 mL 20.9855 mL
5 mM 0.4197 mL 2.0985 mL 4.1971 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (4.36 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0985 mL 10.4927 mL 20.9855 mL 52.4637 mL
5 mM 0.4197 mL 2.0985 mL 4.1971 mL 10.4927 mL
10 mM 0.2099 mL 1.0493 mL 2.0985 mL 5.2464 mL
15 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4976 mL
20 mM 0.1049 mL 0.5246 mL 1.0493 mL 2.6232 mL
25 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
30 mM 0.0700 mL 0.3498 mL 0.6995 mL 1.7488 mL
40 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3116 mL
50 mM 0.0420 mL 0.2099 mL 0.4197 mL 1.0493 mL
60 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8744 mL
80 mM 0.0262 mL 0.1312 mL 0.2623 mL 0.6558 mL
100 mM 0.0210 mL 0.1049 mL 0.2099 mL 0.5246 mL
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SN-001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN-001727699-84-5SN001SN 001STINGStimulator of Interferon GenesTMEM173MITAERISMPYSL929IfnbTBK1IRF3IκBαp65Inhibitorinhibitorinhibit

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