2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. SN-398

SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells.

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SN-398 Chemical Structure

SN-398 Chemical Structure

CAS No. : 124623-00-3

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SN-398 Related Antibodies

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Description

SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1].

Molecular Weight

410.40

Formula

C22H19FN2O5
CAS No.
SMILES

O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC(F)=C4O)=CC5=C1COC([C@]5(O)CC)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SN-398 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN-398124623-00-3SN398SN 398TopoisomeraseAntitumor activityanti-proliferationcamptothecintopoisomeraseinhibitorInhibitorinhibit

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