Sodium diethyldithiocarbamate,98% (Synonyms: Ditiocarb sodium,98%)

Cat. No.: HY-B1637A Assay: 99.2%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Sodium diethyldithiocarbamate,98% (Ditiocarb sodium,98%) is a copper reagent. The reaction with Cu²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethyldithiocarbamate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer.

For research use only. We do not sell to patients.

Sodium diethyldithiocarbamate,98% Chemical Structure

CAS No. : 148-18-5

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
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References
Customer Review

Description

In Vitro

Sodium diethyldithiocarbamate,98% reacts with the Cu²⁺ solution giving a complex of copper diethyldithiocarbamate, which enhances the rate of cementation^[1]. Sodium diethyldithiocarbamate,98% is an agent with strong antioxidant capacity and chelating activities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium diethyldithiocarbamate,98% improves the depressed immune responses of newborn and aged mice. Sodium diethyldithiocarbamate,98% prevents cisplatin nephrotoxicity in animals without reducing the antitumor activity. In that AIDS model, Sodium diethyldithiocarbamate,98% reduces lymphadenopathy and hypergammaglobulinemia, restores immunocompetence, and prolongs survival^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.26

Formula

C₅H₁₀NNaS₂

CAS No.

148-18-5

Appearance

Solid

Color

White to light brown

SMILES

S=C(S[Na])N(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (583.91 mM; Need ultrasonic)

DMSO : 50 mg/mL (291.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8391 mL	29.1954 mL	58.3908 mL
5 mM	1.1678 mL	5.8391 mL	11.6782 mL
10 mM	0.5839 mL	2.9195 mL	5.8391 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.2%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (246 KB) HNMR (115 KB)

Handling Instructions (2659 KB)

References

[1]. Abeer A.El-Saharty, et al. Sodium diethyldithiocarbamate as accelerator of the rate of copper cementation. The Egyptian Journal of Aquatic Research. 2015 Dec, Volume 41(4):289-293.

[2]. Hersh EM, et al. Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study. JAMA. 1991 Mar 27;265(12):1538-44. [Content Brief]

[3]. Dufour P, et al. Sodium dithiocarb as adjuvant immunotherapy for high risk breast cancer: a randomized study. Biotherapy. 1993;6(1):9-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.8391 mL	29.1954 mL	58.3908 mL	145.9769 mL
	5 mM	1.1678 mL	5.8391 mL	11.6782 mL	29.1954 mL
	10 mM	0.5839 mL	2.9195 mL	5.8391 mL	14.5977 mL
	15 mM	0.3893 mL	1.9464 mL	3.8927 mL	9.7318 mL
	20 mM	0.2920 mL	1.4598 mL	2.9195 mL	7.2988 mL
	25 mM	0.2336 mL	1.1678 mL	2.3356 mL	5.8391 mL
	30 mM	0.1946 mL	0.9732 mL	1.9464 mL	4.8659 mL
	40 mM	0.1460 mL	0.7299 mL	1.4598 mL	3.6494 mL
	50 mM	0.1168 mL	0.5839 mL	1.1678 mL	2.9195 mL
	60 mM	0.0973 mL	0.4866 mL	0.9732 mL	2.4329 mL
	80 mM	0.0730 mL	0.3649 mL	0.7299 mL	1.8247 mL
	100 mM	0.0584 mL	0.2920 mL	0.5839 mL	1.4598 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium diethyldithiocarbamate,98% Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium diethyldithiocarbamate,98%148-18-5Ditiocarb sodium,98%HIVBiochemical Assay ReagentsHuman immunodeficiency virusInhibitorinhibitorinhibit

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Sodium diethyldithiocarbamate,98% (Synonyms: Ditiocarb sodium,98%)

Sodium diethyldithiocarbamate,98% Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Sodium diethyldithiocarbamate,98% Related Antibodies

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