2. Natural Products
  3. Plants Flavonoids
  4. Leguminosae Flavonones
  5. Sophora tonkinensis Gagnep.
  6. Sophoranone

Sophoranone  (Synonyms: (-)-Sophoranone; Sophoranon)

Cat. No.: HY-N2529 Purity: 99.67%
SDS COA Handling Instructions

Molarity Calculator

Sophoranone is a flavonoid compound that can be isolated from the root of Sophora subprostrata.

For research use only. We do not sell to patients.

Sophoranone Chemical Structure

Sophoranone Chemical Structure

CAS No. : 23057-55-8

Size Price Stock Quantity
5 mg USD 360 In-stock
10 mg USD 600 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Sophoranone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Sophoranone is a flavonoid compound that can be isolated from the root of Sophora subprostrata[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
28.1 μM
Compound: 3
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
[PMID: 25592708]
Molecular Weight

460.60

Formula

C30H36O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C(C)=C\CC1=C2C(C(C[C@@H](C3=CC(C/C=C(C)\C)=C(C(C/C=C(C)\C)=C3)O)O2)=O)=CC=C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (217.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1711 mL 10.8554 mL 21.7108 mL
5 mM 0.4342 mL 2.1711 mL 4.3422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.67%

SDS (393 KB)

COA (249 KB) HNMR (268 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1711 mL 10.8554 mL 21.7108 mL 54.2770 mL
5 mM 0.4342 mL 2.1711 mL 4.3422 mL 10.8554 mL
10 mM 0.2171 mL 1.0855 mL 2.1711 mL 5.4277 mL
15 mM 0.1447 mL 0.7237 mL 1.4474 mL 3.6185 mL
20 mM 0.1086 mL 0.5428 mL 1.0855 mL 2.7139 mL
25 mM 0.0868 mL 0.4342 mL 0.8684 mL 2.1711 mL
30 mM 0.0724 mL 0.3618 mL 0.7237 mL 1.8092 mL
40 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3569 mL
50 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0855 mL
60 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9046 mL
80 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
100 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5428 mL
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Sophoranone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sophoranone23057-55-8(-)-Sophoranone SophoranonOthersFlavonoidInhibitorinhibitorinhibit

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