2. MAPK/ERK Pathway
  3. JNK
  4. SR-3576

SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM.

For research use only. We do not sell to patients.

SR-3576 Chemical Structure

SR-3576 Chemical Structure

CAS No. : 1164153-22-3

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1 mg USD 95 In-stock
5 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

SR-3576 Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

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JNK1 JNK2 JNK3 JNK

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Description

SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1].

IC50 & Target

JNK3

7 nM (IC50)

Molecular Weight

501.53

Formula

C27H27N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC(NC(NC2=CN(C3=CC(C(NC4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3)N=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (79.76 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9939 mL 9.9695 mL 19.9390 mL
5 mM 0.3988 mL 1.9939 mL 3.9878 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9939 mL 9.9695 mL 19.9390 mL 49.8475 mL
5 mM 0.3988 mL 1.9939 mL 3.9878 mL 9.9695 mL
10 mM 0.1994 mL 0.9969 mL 1.9939 mL 4.9847 mL
15 mM 0.1329 mL 0.6646 mL 1.3293 mL 3.3232 mL
20 mM 0.0997 mL 0.4985 mL 0.9969 mL 2.4924 mL
25 mM 0.0798 mL 0.3988 mL 0.7976 mL 1.9939 mL
30 mM 0.0665 mL 0.3323 mL 0.6646 mL 1.6616 mL
40 mM 0.0498 mL 0.2492 mL 0.4985 mL 1.2462 mL
50 mM 0.0399 mL 0.1994 mL 0.3988 mL 0.9969 mL
60 mM 0.0332 mL 0.1662 mL 0.3323 mL 0.8308 mL
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SR-3576 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-35761164153-22-3SR3576SR 3576JNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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