2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. SR10221

SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

For research use only. We do not sell to patients.

SR10221 Chemical Structure

SR10221 Chemical Structure

CAS No. : 1415321-64-0

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Based on 1 publication(s) in Google Scholar

SR10221 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1].

Molecular Weight

561.11

Formula

C33H37ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](C1=CC=C(C=C1)C(C)(C)C)NC(C2=CC=C(C(C(C)=C3C)=C2)N3CC4=CC(O[C@@H](C)C(O)=O)=C(C=C4)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (222.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7822 mL 8.9109 mL 17.8218 mL
5 mM 0.3564 mL 1.7822 mL 3.5644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7822 mL 8.9109 mL 17.8218 mL 44.5545 mL
5 mM 0.3564 mL 1.7822 mL 3.5644 mL 8.9109 mL
10 mM 0.1782 mL 0.8911 mL 1.7822 mL 4.4555 mL
15 mM 0.1188 mL 0.5941 mL 1.1881 mL 2.9703 mL
20 mM 0.0891 mL 0.4455 mL 0.8911 mL 2.2277 mL
25 mM 0.0713 mL 0.3564 mL 0.7129 mL 1.7822 mL
30 mM 0.0594 mL 0.2970 mL 0.5941 mL 1.4852 mL
40 mM 0.0446 mL 0.2228 mL 0.4455 mL 1.1139 mL
50 mM 0.0356 mL 0.1782 mL 0.3564 mL 0.8911 mL
60 mM 0.0297 mL 0.1485 mL 0.2970 mL 0.7426 mL
80 mM 0.0223 mL 0.1114 mL 0.2228 mL 0.5569 mL
100 mM 0.0178 mL 0.0891 mL 0.1782 mL 0.4455 mL
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SR10221 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR102211415321-64-0SR 10221SR-10221PPARPeroxisome proliferator-activated receptorsbladder cancerInhibitorinhibitorinhibit

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