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  4. SRI-37330 hydrochloride

SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research.

For research use only. We do not sell to patients.

SRI-37330 hydrochloride Chemical Structure

SRI-37330 hydrochloride Chemical Structure

CAS No. : 2322245-49-6

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Based on 1 publication(s) in Google Scholar

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SRI-37330 hydrochloride Related Antibodies

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Description

SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1].

IC50 & Target

TXNIP[1]
In Vitro

SRI-37330 (1 μM, 24 h) hydrochloride inhibits the activity of the human TXNIP promoter in INS-1 cells[1].
SRI-37330 (1 μM, 24 h) hydrochloride inhibits Mrna and protein levels of TXNIP in INS-1 cells[1].
SRI-37330 (5 μM, 24 h) hydrochloride inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter[1].
SRI-37330 (5 μM, 24 h) hydrochloride lowers glucagon secretion in TC1-6 cells[1].
SRI-37330 (0-5 μM, 24 h) hydrochloride inhibits glucagon-induced glucose output from primary hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SRI-37330 hydrochloride Related Antibodies
In Vivo

SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride decreases glucagon secretion and action and blocks hepatic glucose output[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride is well tolerated in male C57BL/6J mice[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

424.87

Formula

C16H20ClF3N4O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(NCC1CN(CCC1)C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)(C)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (235.37 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (147.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3537 mL 11.7683 mL 23.5366 mL
5 mM 0.4707 mL 2.3537 mL 4.7073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.55%

COA (259 KB) HNMR (262 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3537 mL 11.7683 mL 23.5366 mL 58.8415 mL
5 mM 0.4707 mL 2.3537 mL 4.7073 mL 11.7683 mL
10 mM 0.2354 mL 1.1768 mL 2.3537 mL 5.8842 mL
15 mM 0.1569 mL 0.7846 mL 1.5691 mL 3.9228 mL
20 mM 0.1177 mL 0.5884 mL 1.1768 mL 2.9421 mL
25 mM 0.0941 mL 0.4707 mL 0.9415 mL 2.3537 mL
30 mM 0.0785 mL 0.3923 mL 0.7846 mL 1.9614 mL
40 mM 0.0588 mL 0.2942 mL 0.5884 mL 1.4710 mL
50 mM 0.0471 mL 0.2354 mL 0.4707 mL 1.1768 mL
60 mM 0.0392 mL 0.1961 mL 0.3923 mL 0.9807 mL
80 mM 0.0294 mL 0.1471 mL 0.2942 mL 0.7355 mL
100 mM 0.0235 mL 0.1177 mL 0.2354 mL 0.5884 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SRI-37330 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRI-373302322245-49-6SRI37330SRI 37330Otherstype 2 diabetesthioredoxin-interacting proteinTXNIPInhibitorinhibitorinhibit

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