SRI-37330 hydrochloride

Name: SRI-37330 hydrochloride
Brand: MedChemExpress
SKU: HY-141623
Rating: 4.5 (1 reviews)

Cat. No.: HY-141623 Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research.

For research use only. We do not sell to patients.

SRI-37330 hydrochloride Chemical Structure

CAS No. : 2322245-49-6

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SRI-37330 hydrochloride:

SRI-37330 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TXNIP^[1]

In Vitro

SRI-37330 (1 μM, 24 h) hydrochloride inhibits the activity of the human TXNIP promoter in INS-1 cells^[1].
SRI-37330 (1 μM, 24 h) hydrochloride inhibits Mrna and protein levels of TXNIP in INS-1 cells^[1].
SRI-37330 (5 μM, 24 h) hydrochloride inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter^[1].
SRI-37330 (5 μM, 24 h) hydrochloride lowers glucagon secretion in TC1-6 cells^[1].
SRI-37330 (0-5 μM, 24 h) hydrochloride inhibits glucagon-induced glucose output from primary hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride decreases glucagon secretion and action and blocks hepatic glucose output^[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride is well tolerated in male C57BL/6J mice^[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.87

Formula

C₁₆H₂₀ClF₃N₄O₂S

CAS No.

2322245-49-6

Appearance

Solid

Color

White to light yellow

SMILES

O=S(NCC1CN(CCC1)C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)(C)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (235.37 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (147.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3537 mL	11.7683 mL	23.5366 mL
5 mM	0.4707 mL	2.3537 mL	4.7073 mL
10 mM	0.2354 mL	1.1768 mL	2.3537 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (259 KB) HNMR (258 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Thielen LA, et al. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.3537 mL	11.7683 mL	23.5366 mL	58.8415 mL
	5 mM	0.4707 mL	2.3537 mL	4.7073 mL	11.7683 mL
	10 mM	0.2354 mL	1.1768 mL	2.3537 mL	5.8842 mL
	15 mM	0.1569 mL	0.7846 mL	1.5691 mL	3.9228 mL
	20 mM	0.1177 mL	0.5884 mL	1.1768 mL	2.9421 mL
	25 mM	0.0941 mL	0.4707 mL	0.9415 mL	2.3537 mL
	30 mM	0.0785 mL	0.3923 mL	0.7846 mL	1.9614 mL
	40 mM	0.0588 mL	0.2942 mL	0.5884 mL	1.4710 mL
	50 mM	0.0471 mL	0.2354 mL	0.4707 mL	1.1768 mL
	60 mM	0.0392 mL	0.1961 mL	0.3923 mL	0.9807 mL
	80 mM	0.0294 mL	0.1471 mL	0.2942 mL	0.7355 mL
	100 mM	0.0235 mL	0.1177 mL	0.2354 mL	0.5884 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.