1. Metabolic Enzyme/Protease Apoptosis
  2. Endogenous Metabolite Apoptosis
  3. Stachyose hydrate

Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture .

For research use only. We do not sell to patients.

Stachyose hydrate Chemical Structure

Stachyose hydrate Chemical Structure

CAS No. : 54261-98-2

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Based on 1 publication(s) in Google Scholar

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Description

Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture [1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Stachyose hydrate (3.2 mg/mL, 36 h, 48 h) induces apoptotic-like programmed cell death in Nicotiana benthamiana leaf cells, characterized by nuclear DNA fragmentation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[3]

Cell Line: Nicotiana benthamiana leaf cells (tobacco, plant)
Concentration: 3.2 mg/mL
Incubation Time: 36 h, 48 h
Result: Resulted in nuclear DNA fragmentation.
Induced apoptotic-like programmed cell death.
In Vivo

Stachyose hydrate (200, 400, 600 mg/kg, p.o., once daily for 3 weeks) alleviates colitis symptoms, restores intestinal barrier integrity, and modulates pro-inflammatory and anti-inflammatory cytokine expression in DSS (HY-116282C)-induced ulcerative colitis C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS (HY-116282C)-induced ulcerative colitis C57BL/6J mouse model[2]
Dosage: 200, 400, 600 mg/kg
Administration: Oral gavage (p.o.), once daily for 3 weeks
Result: Significantly alleviated colitis symptoms in DSS-induced colitis mice, including reducing weight loss, lowering disease activity index (DAI), and increasing colon length, while restoring colonic epithelial barrier integrity.
Dose-dependently upregulated mRNA expression of ZO-1, Claudin-1, and Occludin, reduced IL-17, TNF-α, IL-1β, and IL-6 expression, and increased IL-10 levels.
Clinical Trial
Formula

C24H42O21.xH2O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@](O[C@@H]1CO)([C@H]([C@@H]1O)O)O[C@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO[C@H]([C@@H]([C@H]3O)O)O[C@@H]([C@@H]3O)CO[C@H]([C@@H]([C@H]4O)O)O[C@@H]([C@@H]4O)CO.[x H2O]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (Need ultrasonic)

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Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Stachyose hydrate
Cat. No.:
HY-N0299
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