2. Immunology/Inflammation
  3. STING
  4. C-178

C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.

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C-178 Chemical Structure

C-178 Chemical Structure

CAS No. : 329198-87-0

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Based on 4 publication(s) in Google Scholar

C-178 Related Antibodies

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Description

C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1].
IC50 & Target

STING[1]
In Vitro

C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells[1].
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1[1].
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages[1].
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-178 Related Antibodies

Western Blot Analysis[1]

Cell Line: Mouse bone marrow-derived macrophages (BMDMs)
Concentration: 0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
Incubation Time: 1 hour
Result: Inhibited CMA-induced p-TBK1 expression as a does dependent manner.

RT-PCR[1]

Cell Line: Mouse bone marrow-derived macrophages (BMDMs)
Concentration: 1 μM
Incubation Time: 1 hour
Result: Downregulated Ifnb1 expression in BMDMs.
Molecular Weight

322.27

Formula

C17H10N2O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (129.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1030 mL 15.5149 mL 31.0299 mL
5 mM 0.6206 mL 3.1030 mL 6.2060 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1030 mL 15.5149 mL 31.0299 mL 77.5747 mL
5 mM 0.6206 mL 3.1030 mL 6.2060 mL 15.5149 mL
10 mM 0.3103 mL 1.5515 mL 3.1030 mL 7.7575 mL
15 mM 0.2069 mL 1.0343 mL 2.0687 mL 5.1716 mL
20 mM 0.1551 mL 0.7757 mL 1.5515 mL 3.8787 mL
25 mM 0.1241 mL 0.6206 mL 1.2412 mL 3.1030 mL
30 mM 0.1034 mL 0.5172 mL 1.0343 mL 2.5858 mL
40 mM 0.0776 mL 0.3879 mL 0.7757 mL 1.9394 mL
50 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5515 mL
60 mM 0.0517 mL 0.2586 mL 0.5172 mL 1.2929 mL
80 mM 0.0388 mL 0.1939 mL 0.3879 mL 0.9697 mL
100 mM 0.0310 mL 0.1551 mL 0.3103 mL 0.7757 mL
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C-178 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-178329198-87-0C178C 178STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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