2. Autophagy
  3. Autophagy
  4. STL001

STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.

For research use only. We do not sell to patients.

STL001 Chemical Structure

STL001 Chemical Structure

CAS No. : 3047493-70-6

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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

STL001 Related Antibodies

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Description

STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies[1].

In Vitro

STL001 (1-10 μM; 24 h) causes a dose-dependent reduction of the cellular levels of FOXM1 protein[1].
STL001 (5 μM; 24 h) induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STL001 Related Antibodies

Western Blot Analysis[1]

Cell Line: OVCAR-8, ES-2, HCT-116, HCT-FET, FLO-1, TAM-R, HCC-1143, 22Rv1, LNCaP
Concentration: 1 μM, 5 μM, and 10 μM
Incubation Time: 24 h
Result: Significantly reduced the cellular levels of FOXM1 protein.

Western Blot Analysis[1]

Cell Line: U2OS-C3-luc cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.
Molecular Weight

509.52

Formula

C27H23N7O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9626 mL 9.8132 mL 19.6263 mL
5 mM 0.3925 mL 1.9626 mL 3.9253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9626 mL 9.8132 mL 19.6263 mL 49.0658 mL
5 mM 0.3925 mL 1.9626 mL 3.9253 mL 9.8132 mL
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STL001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STL0013047493-70-6STL 001STL-001AutophagyFOXM1 inhibitorautophagic degradationLC3Inhibitorinhibitorinhibit

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