2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite HIV Antibiotic Endogenous Metabolite
  4. Sulfadoxine-d4

Sulfadoxine-d4  (Synonyms: Sulphadoxine-d4)

Cat. No.: HY-B0439S Purity: ≥98.0%
COA Handling Instructions

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Sulfadoxine-d4 is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

For research use only. We do not sell to patients.

Sulfadoxine-d<sub>4</sub> Chemical Structure

Sulfadoxine-d4 Chemical Structure

CAS No. : 1330266-05-1

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1 mg USD 140 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sulfadoxine-d4:

Sulfadoxine-d4 Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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HIV HIV-1 HIV-2

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

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Description

Sulfadoxine-d4 is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

IC50 & Target

Plasmodium

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfadoxine-d4 Related Antibodies
Molecular Weight

314.35

Formula

C12H10D4N4O4S
CAS No.
Unlabeled CAS

2447-57-6
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=NC=NC(OC)=C2OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (318.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (318.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1812 mL 15.9058 mL 31.8117 mL
5 mM 0.6362 mL 3.1812 mL 6.3623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.1812 mL 15.9058 mL 31.8117 mL 79.5292 mL
5 mM 0.6362 mL 3.1812 mL 6.3623 mL 15.9058 mL
10 mM 0.3181 mL 1.5906 mL 3.1812 mL 7.9529 mL
15 mM 0.2121 mL 1.0604 mL 2.1208 mL 5.3019 mL
20 mM 0.1591 mL 0.7953 mL 1.5906 mL 3.9765 mL
25 mM 0.1272 mL 0.6362 mL 1.2725 mL 3.1812 mL
30 mM 0.1060 mL 0.5302 mL 1.0604 mL 2.6510 mL
40 mM 0.0795 mL 0.3976 mL 0.7953 mL 1.9882 mL
50 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5906 mL
60 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3255 mL
80 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9941 mL
100 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7953 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sulfadoxine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfadoxine-d41330266-05-1Sulphadoxine-d4ParasiteHIVAntibioticEndogenous MetaboliteHuman immunodeficiency virusInhibitorinhibitorinhibit

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