Syk-IN-6

Cat. No.: HY-151634: FAQs
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Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Syk-IN-6 Chemical Structure

CAS No. : 3018859-95-2

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

ERK2

ERK1

STAT3

STAT5

In Vitro

Syk-IN-6 (WC36) specifically and potently suppresses oncogenic activities of Syk in AML cell lines and patient-derived AML cells^[1].
Syk-IN-6 (5 μM; 16 h) inhibits FcγRI-specific antibody (IgG2)-stimulated phosphorylation of Syk, STAT3/STAT5 and ERK1/2 in naive MV4-11 cells rather not entospletinib-resistant/Syk-deficient MV4-11 cells^[1].
Syk-IN-6 (0.01 μM-100 μM; 16 h) inhibits the proliferation of MV4-11 cells, HL-60 and patient-derived AML cells by SykcSH2 dose-dependently^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Raji B cell, HL-60 cell, naive and entospletinib-resistant MV4-11 cells
Concentration:	5 μM, 10 μM
Incubation Time:	16 hours
Result:	Suppressed the phosphorylation and activation of Syk, ERK1/2 and STAT3/5 in entospletinib-resistant MV4-11 cells. Was potent against phosphorylation of ERK1/2 and STAT3 in HL-60 cells. Inhibited phosphorylation of Syk, ERK1/2 and STAT3/5 in AML cells from four patients refractory or relapsed following standard AML therapies.

Molecular Weight

390.44

Formula

C₂₁H₂₂N₆O₂

CAS No.

3018859-95-2

SMILES

O=C(C(C(NC1=NC=CC=N1)C2=CNC3=C2C=CC=C3)=[N+]=[N-])OC4CCCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Singaram I, et al. Targeting lipid-protein interaction to treat Syk-mediated acute myeloid leukemia. Nat Chem Biol. 2022 Oct 13. [Content Brief]

Syk-IN-6 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syk-IN-63018859-95-2SykSTATERKSpleen tyrosine kinaseExtracellular signal regulated kinaseshematopoietic malignanciesacute myeloid leukemiaAMLInhibitorinhibitorinhibit

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