1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Talinolol

Talinolol  (Synonyms: Cordanum)

Cat. No.: HY-108286 Purity: 99.64%
COA Handling Instructions

Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity.

For research use only. We do not sell to patients.

Talinolol Chemical Structure

Talinolol Chemical Structure

CAS No. : 57460-41-0

Size Price Stock Quantity
5 mg USD 55 In-stock
10 mg USD 104 In-stock
25 mg USD 230 In-stock
50 mg USD 400 In-stock
100 mg USD 700 In-stock
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Description

Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity[1][2].

IC50 & Target[1]

Beta-1 adrenergic receptor

 

In Vitro

Human OATP1A2-, rat Oatp1a5-, and rat Mdr1a-mediated Talinolol transport can be inhibited by naringin, with IC50s of 343, 12.7, and 604 μM, respectively, in LLC-PK1 cell and Xenopus laevis oocyte systems[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Talinolol (20 mg/kg; i.p.) plasma and liver AUC0-5 h are increased by Zosuquidar administration[2].
Bioavailability of Talinolol can be enhanced by coadministration with grapefruit juice (GFJ) in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.49

Formula

C20H33N3O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(OCC(O)CNC(C)(C)C)C=C1)NC2CCCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (275.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7511 mL 13.7555 mL 27.5111 mL
5 mM 0.5502 mL 2.7511 mL 5.5022 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.64%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7511 mL 13.7555 mL 27.5111 mL 68.7777 mL
5 mM 0.5502 mL 2.7511 mL 5.5022 mL 13.7555 mL
10 mM 0.2751 mL 1.3756 mL 2.7511 mL 6.8778 mL
15 mM 0.1834 mL 0.9170 mL 1.8341 mL 4.5852 mL
20 mM 0.1376 mL 0.6878 mL 1.3756 mL 3.4389 mL
25 mM 0.1100 mL 0.5502 mL 1.1004 mL 2.7511 mL
30 mM 0.0917 mL 0.4585 mL 0.9170 mL 2.2926 mL
40 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7194 mL
50 mM 0.0550 mL 0.2751 mL 0.5502 mL 1.3756 mL
60 mM 0.0459 mL 0.2293 mL 0.4585 mL 1.1463 mL
80 mM 0.0344 mL 0.1719 mL 0.3439 mL 0.8597 mL
100 mM 0.0275 mL 0.1376 mL 0.2751 mL 0.6878 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Talinolol
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