Tanshinol borneol ester

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Tanshinol borneol ester, an angiogenesis stimulator, promoted multiple key steps of angiogenesis through Akt and MAPK signalling pathways. Tanshinol borneol ester has anti-ischemic and anti-atherosclerosis activities.

For research use only. We do not sell to patients.

Tanshinol borneol ester Chemical Structure

CAS No. : 1623012-10-1

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•Related Small Molecules:

•Related Proteins:

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Akt Akt1 Akt2 Akt3

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Akt

AMPK

In Vivo

Tanshinol borneol ester (DBZ; 0.2, 1, and 5 mg/kg; IP; daily; 8 days) produces significant increases in blood content and microvessel formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mouse Matrigel plug model^[1]
Dosage:	0.2, 1, and 5 mg/kg
Administration:	IP; daily; 8 days
Result:	Produced significant increases in blood content compared with vehicle control, while no significant increase in haemoglobin content at the highest dose (25 mg/kg). Significantly increased microvessel formation.

Molecular Weight

334.41

Formula

C₁₉H₂₆O₅

CAS No.

1623012-10-1

SMILES

C[C@](C1(C)C)(CC[C@]1([H])C2)[C@H]2OC([C@H](O)CC(C=C3)=CC(O)=C3O)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sha Liao, et al. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. [Content Brief]

[2]. Pu Jia, et al. The anti-atherosclerotic effect of tanshinol borneol ester using fecal metabolomics based on liquid chromatography-mass spectrometry. Analyst. 2016 Feb 7;141(3):1112-20. [Content Brief]