TAO Kinase inhibitor 2

Cat. No.: HY-153752 Purity: ≥97.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC₅₀=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC₅₀s of 50-500 nM.

For research use only. We do not sell to patients.

TAO Kinase inhibitor 2 Chemical Structure

CAS No. : 850467-77-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC₅₀=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC₅₀s of 50-500 nM^[1].

Molecular Weight

400.47

Formula

C₂₅H₂₄N₂O₃

CAS No.

850467-77-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)OC2=CC=CC=C2)NCC(NC3C4=C(CCC3)C=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (249.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4971 mL	12.4853 mL	24.9707 mL
5 mM	0.4994 mL	2.4971 mL	4.9941 mL
10 mM	0.2497 mL	1.2485 mL	2.4971 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (245 KB) HNMR (159 KB)

Handling Instructions (2659 KB)

References

[1]. Deborah Lynn Baly, et al. Tao kinase modulators and methods of use. Patent. WO2005040355.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4971 mL	12.4853 mL	24.9707 mL	62.4266 mL
	5 mM	0.4994 mL	2.4971 mL	4.9941 mL	12.4853 mL
	10 mM	0.2497 mL	1.2485 mL	2.4971 mL	6.2427 mL
	15 mM	0.1665 mL	0.8324 mL	1.6647 mL	4.1618 mL
	20 mM	0.1249 mL	0.6243 mL	1.2485 mL	3.1213 mL
	25 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4971 mL
	30 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0809 mL
	40 mM	0.0624 mL	0.3121 mL	0.6243 mL	1.5607 mL
	50 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0404 mL
	80 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL